公开(公告)号：US11744820B2

公开(公告)日：2023-09-05

申请号：US17447178

申请日：2021-09-08

申请人： Axial Therapeutics, Inc. ,  California Institute of Technology

发明人： Timothy Sampson ,  Sarkis Mazmanian ,  Anthony Stewart Campbell

IPC分类号： A61K31/353 ,  A61P25/28 ,  A61P25/16 ,  A61K31/05 ,  A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/465 ,  A61K31/522 ,  A61K45/06

CPC分类号： A61K31/353 ,  A61K31/05 ,  A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/465 ,  A61K31/522 ,  A61K45/06 ,  A61P25/16 ,  A61P25/28

摘要： The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.

公开(公告)号：US11147792B2

公开(公告)日：2021-10-19

申请号：US16611406

申请日：2018-05-14

申请人： Axial Therapeutics, Inc ,  California Institute of Technology

发明人： Timothy Sampson ,  Sarkis Mazmanian ,  Anthony Stewart Campbell

IPC分类号： A61K31/353 ,  A61P25/28 ,  A61P25/16 ,  A61K31/05 ,  A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/465 ,  A61K31/522 ,  A61K45/06

摘要： The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.

公开(公告)号：US20200163933A1

公开(公告)日：2020-05-28

申请号：US16611406

申请日：2018-05-14

申请人： Axial Biotherapeutics, Inc. ,  California Institute of Technology

发明人： Timothy Sampson ,  Sarkis Mazmanian ,  Anthony Stewart Campbell

IPC分类号： A61K31/353 ,  A61P25/28 ,  A61K31/05 ,  A61K31/522 ,  A61P25/16 ,  A61K31/216 ,  A61K31/235 ,  A61K31/465 ,  A61K31/192 ,  A61K45/06

摘要： The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.