公开(公告)号：US20170058246A1

公开(公告)日：2017-03-02

申请号：US14838575

申请日：2015-08-28

Applicant: Axion BioSystems, Inc.

Inventor： Robert Dixon Grier, JR. ,  David Ernest Irvine ,  James David Ross

IPC: C12M1/12 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00

CPC classification number: C12M41/34 ,  C12M23/04 ,  C12M23/12 ,  C12M23/40 ,  C12M23/42 ,  C12M23/44 ,  C12M41/14

Abstract: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.

Abstract translation: 提供了用于促进细胞和材料在配置用于高通量应用的培养板中的放置的装置，系统和方法。 培养系统具有培养板，该培养板具有用于引导将细胞和材料放置在培养板的各个培养孔中的盖子。 盖子可以提供与包括生物传感器板和生物培养板的电生理学培养板的耦合，其中生物传感器板位于培养皿板下并且连接到培养皿板，使得每个生物传感器可操作地偶联到多个培养物的一个培养物 井。 本文还提供了物理地影响接收在培养板中的流体定位的容纳装置。

公开(公告)号：US10351812B2

公开(公告)日：2019-07-16

申请号：US14838575

申请日：2015-08-28

Applicant: Axion BioSystems, Inc.

Inventor： Robert Dixon Grier, Jr. ,  David Ernest Irvine ,  James David Ross

IPC: C12M1/00 ,  C12M1/12 ,  C12M1/32 ,  C12M1/34 ,  C12M3/00

Abstract: Systems and methods for creating a localized environment for a cell culture plate are described herein. An example system can include a dock shaped to receive the cell culture plate, and a gas distribution device positioned on the dock. The gas distribution device can include a frame including a plurality of sides connected to form an opening, an internal channel within the frame for directing a gas mixture within the gas distribution device, an inlet port in fluid communication with the internal channel for receiving the gas mixture, and a plurality of apertures in fluid communication with the internal channel. The plurality of apertures can be spaced apart from one another along the frame and configured to direct the gas mixture toward the opening.