公开(公告)号：US20090286780A1

公开(公告)日：2009-11-19

申请号：US12394548

申请日：2009-02-27

申请人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Hidefumi OZAWA ,  Ayako TOSAKA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Sayaka KUROBUCHI ,  Yuuichirou WATANABE ,  Kimiyuki SHIBUYA

发明人： Ayumu OKUDA ,  Takayuki MATSUDA ,  Toru MIURA ,  Hidefumi OZAWA ,  Ayako TOSAKA ,  Koichi YAMAZAKI ,  Yuki YAMAGUCHI ,  Sayaka KUROBUCHI ,  Yuuichirou WATANABE ,  Kimiyuki SHIBUYA

IPC分类号： A61K31/4178 ,  C07D407/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P3/00 ,  A61P25/00 ,  A61P17/00

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRβ激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。