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公开(公告)号:US07919509B2
公开(公告)日:2011-04-05
申请号:US12394548
申请日:2009-02-27
申请人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
发明人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
IPC分类号: A61K31/4166 , A61K31/427 , A61K31/45 , A61K31/422 , A61K31/4525 , C07D405/12 , C07D417/12 , C07D413/12 , C07D407/12
CPC分类号: C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要: To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译: 提供一种新颖的LXR&bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式(1)表示的2-氧代色烯衍生物或其盐或其溶剂合物。
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公开(公告)号:US07576203B2
公开(公告)日:2009-08-18
申请号:US11631397
申请日:2005-06-30
申请人: Kimiyuki Shibuya , Ayako Tosaka
发明人: Kimiyuki Shibuya , Ayako Tosaka
IPC分类号: C07D213/76 , C07D401/12
CPC分类号: C07D213/75 , C07D401/12 , C07D413/12
摘要: The present invention provides an industrially useful method for synthesizing a cyclic diamine derivative (4) or a salt thereof which serves as an ACAT inhibitor.A 2-hydroxyacetylaminopyridine compound represented by formula (1), and a method for producing a cyclic diamine derivative represented by formula (4) or a salt thereof from compound (1) through 1) Step A-1, 2) Steps B-1 and B-2, or 3) Steps B-1, B-3, and B-4.
摘要翻译: 本发明提供用作合成作为ACAT抑制剂的环状二胺衍生物(4)或其盐的工业上有用的方法。 由式(1)表示的2-羟基乙酰基氨基吡啶化合物和由式(4)表示的环状二胺衍生物或其盐从化合物(1)至1)步骤A-1,2)步骤B-1 和B-2,或3)步骤B-1,B-3和B-4。
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公开(公告)号:US20080045714A1
公开(公告)日:2008-02-21
申请号:US11631397
申请日:2005-06-30
申请人: Kimiyuki Shibuya , Ayako Tosaka
发明人: Kimiyuki Shibuya , Ayako Tosaka
IPC分类号: C07D405/14
CPC分类号: C07D213/75 , C07D401/12 , C07D413/12
摘要: The present invention provides an industrially useful method for synthesizing a cyclic diamine derivative (4) or a salt thereof which serves as an ACAT inhibitor. A 2-hydroxyacetylaminopyridine compound represented by formula (1), and a method for producing a cyclic diamine derivative represented by formula (4) or a salt thereof from compound (1) through 1) Step A-1, 2) Steps B-1 and B-2, or 3) Steps B-1, B-3, and B-4.
摘要翻译: 本发明提供用作合成作为ACAT抑制剂的环状二胺衍生物(4)或其盐的工业上有用的方法。 由式(1)表示的2-羟基乙酰基氨基吡啶化合物和由式(4)表示的环状二胺衍生物或其盐从化合物(1)至1)步骤A-1,2)步骤B-1 和B-2,或3)步骤B-1,B-3和B-4。
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