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公开(公告)号：US20200063155A1
公开(公告)日：2020-02-27
申请号：US16489620
申请日：2018-03-01
发明人： Marc Linka , Fabien Poree , Bernd Laber , Gudrun Lange , Christina Thies , Ernst Weber , Michael Strerath , Sandra Geske , Heike Balven-Ross , Nina Wobst , Wayne Coco , Nikolaus Pawlowski , Jan Tebbe , Manuel Dubald
IPC分类号： C12N15/82 , C12N9/02 , C12N15/52 , C07K14/415
摘要： In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
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公开(公告)号：US20200239905A1
公开(公告)日：2020-07-30
申请号：US16489996
申请日：2018-03-01
发明人： Marc Linka , Fabien Poree , Bernd Laber , Gudrun Lange , Ernst Weber , Michael Strerath , Sandra Geske , Heike Balven-Ross , Nina Wobst , Wayne Coco , Nikolaus Pawlowski , Jan Tebbe , Christina Thies , Manuel Dubald
摘要： In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
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公开(公告)号：US11180770B2
公开(公告)日：2021-11-23
申请号：US16489620
申请日：2018-03-01
发明人： Marc Linka , Fabien Poree , Bernd Laber , Gudrun Lange , Christina Thies , Ernst Weber , Michael Strerath , Sandra Geske , Heike Balven-Ross , Nina Wobst , Wayne Coco , Nikolaus Pawlowski , Jan Tebbe , Manuel Dubald
IPC分类号： C12N15/82 , C07K14/195 , C07K14/415 , C12N9/02 , C12N15/52
摘要： In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
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公开(公告)号：US11371056B2
公开(公告)日：2022-06-28
申请号：US16489996
申请日：2018-03-01
发明人： Marc Linka , Fabien Poree , Bernd Laber , Gudrun Lange , Ernst Weber , Michael Strerath , Sandra Geske , Heike Balven-Ross , Nina Wobst , Wayne Coco , Nikolaus Pawlowski , Jan Tebbe , Christina Thies , Manuel Dubald
IPC分类号： C12N15/82 , C12N9/02 , C12N15/52 , C07K14/195
摘要： In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
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公开(公告)号：US10597674B2
公开(公告)日：2020-03-24
申请号：US15758429
申请日：2016-09-08
发明人： Marc Linka , Fabien Poree , Bernd Laber , Gudrun Lange , Jan Tebbe , Wayne Coco , Michael Strerath , Ernst Weber , Nikolaus Pawlowski , Sandra Geske , Heike Balven-Ross , Nina Wobst , Christina Thies , Manuel Dubald
摘要： In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
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