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公开(公告)号:US20220267247A1
公开(公告)日:2022-08-25
申请号:US17625414
申请日:2020-07-06
Applicant: BASF CORPORATION , California Institute of Technology
Inventor: Sarah Reisman , Michael Rombola , Carolyn L. Ladd , Martin John McLaughlin , Stephen Zuend , Roland Goetz
IPC: C07C67/293 , C07B53/00
Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a′, R10b′, R10c′, R10d′, Z and Z′ have the meanings as defined in the description.
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公开(公告)号:US11926589B2
公开(公告)日:2024-03-12
申请号:US17625414
申请日:2020-07-06
Applicant: BASF CORPORATION , California Institute of Technology
Inventor: Sarah Reisman , Michael Rombola , Carolyn L. Ladd , Martin John McLaughlin , Stephan Zuend , Roland Goetz
IPC: C07C67/293 , C07B53/00
CPC classification number: C07C67/293 , C07B53/00 , C07B2200/07
Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a′, R10b′, R10c′, R10d′, Z and Z′ have the meanings as defined in the description.
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