公开(公告)号：US20210387156A1

公开(公告)日：2021-12-16

申请号：US17290669

申请日：2019-10-29

申请人： BASF SE

发明人： Bernd Dieter OSCHMANN ,  Kerstin MUELHEIMS ,  Wolfgang KRAUSE ,  Patrick LEIBACH ,  Roland Hinrich STAFF ,  Dieter FLICK ,  Lukas MAYR ,  Stephanie RENZ ,  Felicitas GUTH ,  Klaus KAHLE ,  Stephan HUEFFER ,  Tobias Maximilian MERKEL ,  Axel BINDER ,  Karl KOLTER ,  Yean Yik GEOERG ,  Regina VOGELSANG ,  Antoine Maxime Charles Jos BEZIAU

IPC分类号： B01J13/20 ,  B01J13/22

摘要： The present invention relates to processes for producing microparticles having, in their interior, at least one cavity which is connected via pores to the surface of the microparticles and which have been laden with at least one organic active of low molecular weight. The invention especially relates to a process for loading microparticles with at least one organic active of low molecular weight, wherein the active has been embedded in a matrix and/or the pores of the microparticles have been closed by means of a substance applied to the surface of the microparticles. The invention additionally relates to a process for sealing microparticles laden with at least one organic active of low molecular weight. The invention also relates to compositions of microparticles laden with at least one active of low molecular weight and to the use thereof.

公开(公告)号：US20210024715A1

公开(公告)日：2021-01-28

申请号：US17045691

申请日：2019-04-04

申请人： BASF SE

发明人： Bernd Dieter OSCHMANN ,  Wolfgang KRAUSE ,  Patrick LEIBACH ,  Kerstin MUELHEIMS ,  Ralf PELZER ,  Ewelina BURAKOWSKA-MEISE

IPC分类号： C08J9/00 ,  A61K8/11 ,  A61K8/02 ,  A61K8/85 ,  A61K9/16 ,  C11D3/50 ,  C11D3/37

摘要： The present invention relates to a composition of spherical microparticles composed of a wall material and at least one cavity that comprises a gas and/or a liquid, which have pores on the surface thereof, wherein the spherical microparticles have a mean particle diameter of 10-600 μm and wherein at least 80% of those microparticles, the particle diameter of which does not deviate from the mean particle diameter of the microparticles of the composition by more than 20%, each have on average at least 10 pores, the diameter of which is in the range from 1/5000 to 1/5 of the mean particle diameter, and, furthermore, the diameter of each of these pores is at least 20 nm, wherein the wall material consists of a composition comprising at least one aliphatic-aromatic polyester and at least one additional polymer, wherein the additional polymer is selected from the group consisting of polyhydroxy fatty acids, poly(p-dioxanones), polyanhydrides, polyesteramides, polysaccharides and proteins, to a method for the preparation thereof and use thereof.