-
公开(公告)号：US20200010395A1
公开(公告)日：2020-01-09
申请号：US16460402
申请日：2019-07-02
Applicant: BASF SE
Inventor： Dagmar Pascale KUNSMANN-KEITEL , Georg Heinrich GROSCH , Jan-Dirk ARNDT , Gauthier Luc Maruice AVERLANT , Wolf-Steffen WEISSKER , Marcus Georg SCHREMS , Dan-Tam Daniel TANG
Abstract: Method for preparing a β-hydroxyketone having 4 to 8 carbon atoms by reacting formaldehyde with a branched or unbranched dialkyl ketone having 3 to 7 carbon atoms in the liquid phase in a reactor in the presence of a basic component at a temperature of 50 to 150° C. and a pressure of 0.2 to 10 MPa abs, in which (a) a trialkylamine having 1 to 4 carbon atoms per alkyl group is used as basic component and the reaction (b) is carried out in the presence of 1 to 25% by weight water, based on the liquid phase, and (c) at a molar ratio of trialkylamine to formaldehyde in the liquid phase of from 1 to 5.
-
公开(公告)号：US20200010394A1
公开(公告)日：2020-01-09
申请号：US16460327
申请日：2019-07-02
Applicant: BASF SE
Inventor： Dagmar Pascale KUNSMANN-KEITEL , Georg Heinrich GROSCH , Jan-Dirk ARNDT , Gauthier Luc Maruice AVERLANT , Wolf-Steffen WEISSKER , Marcus Georg SCHREMS , Dan-Tam Daniel TANG
Abstract: Method for preparing 1-hydroxy-2-methyl-3-pentanone (I) by reacting formaldehyde with diethyl ketone in a reactor in the presence of water and a basic component at a temperature of 50 to 150° C. and a pressure of 0.2 to 10 MPa abs, in which the basic component used is a trialkylamine from the group comprising trimethylamine, N,N-dimethylethylamine, N,N-diethylmethylamine, triethylamine, N,N-dimethyl-n-propylamine, N-ethyl-N-methyl-n-propylamine, N,N-dimethylisopropylamine, N-ethyl-N-methylisopropylamine, N,N-dimethyl-n-butylamine, N,N-dimethylisobutylamine and N,N-dimethyl-sec-butylamine, and from the reaction mixture obtained, trialkylamine as low boiler and a bottom product comprising 1-hydroxy-2-methyl-3-pentanone (I) as high boiler are separated in a distillation apparatus, wherein the distillation apparatus is operated at a top pressure of 0.2 to 1 MPa abs.
-
公开(公告)号：US20130345475A1
公开(公告)日：2013-12-26
申请号：US13922619
申请日：2013-06-20
Applicant: BASF SE
Inventor： Marcus Georg SCHREMS
IPC: C07C209/68
CPC classification number: C07C209/68 , C07C209/88 , C07C211/30
Abstract: Many optically active amines are valuable pharmaceuticals and intermediates for the preparation of active compounds. It is frequently the case that only one of the two enantiomers is active or not harmful, so that isolation of this enantiomer from the racemic mixture is necessary. Processes for racemate resolution make it possible to separate racemic mixtures into their enantiomers. Here, it is useful to once again racemize the enantiomer which is not required and recirculate it to racemate resolution and thus improve the yield of the desired enantiomer. The present invention relates to processes for the racemization of optically active amines, in particular arylalkylamines, in the presence of hydrogen and a hydrogenation/dehydrogenation catalyst comprising nickel, cobalt and copper as active components at elevated temperature.
Abstract translation: 许多光学活性胺是制备活性化合物的有价值的药物和中间体。 通常情况下，两种对映异构体中只有一种是有活性的或无害的，因此该对映异构体与外消旋混合物的分离是必要的。 外消旋体拆分方法可以将外消旋混合物分离成其对映异构体。 这里，再次使不需要的对映异构体外消旋化并将其再循环到外消旋体拆分是有用的，从而提高所需对映体的产率。 本发明涉及在氢气存在下光学活性胺，特别是芳基烷基胺外消旋化的方法和在升高的温度下包含镍，钴和铜作为活性组分的氢化/脱氢催化剂。
-
-
Search Results
3
records
(took 0.011 seconds)
