公开(公告)号：US20240252507A1

公开(公告)日：2024-08-01

申请号：US18454595

申请日：2023-08-23

申请人： Essentialis, Inc.

发明人： Neil M. COWEN ,  Khaled A. YAMOUT

IPC分类号： A61K31/549 ,  A61K9/20 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

CPC分类号： A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic an compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

公开(公告)号：US11858875B2

公开(公告)日：2024-01-02

申请号：US17874851

申请日：2022-07-27

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： William M. Lamanna ,  Michael J. Bulinski ,  Sean M. Smith ,  Alexandre R. Monteil ,  Michael G. Costello ,  John G. Owens

IPC分类号： C07C209/68 ,  C07D295/067 ,  C09K5/10 ,  H01M8/04029 ,  H01M8/04701 ,  H05K7/20

CPC分类号： C07C209/68 ,  C07D295/067 ,  C09K5/10 ,  H01M8/04029 ,  H01M8/04701 ,  H05K7/20218

摘要： A composition includes a perfluorinated propenylamine represented by the following general formula (1):




Each occurrence of Rf1 and Rf2 is:

(i) independently a linear or branched perfluoroalkyl group having 1-8 carbon atoms and optionally comprises one or more catenated heteroatoms; or
(ii) bonded together to form a ring structure having 4-8 carbon atoms and that optionally comprises one or more catenated heteroatoms.


At least 60 wt. % of the perfluorinated propenylamine is in the form of the E isomer, based on the total weight of the perfluorinated propenylamine in the composition.

公开(公告)号：US11788107B2

公开(公告)日：2023-10-17

申请号：US17262269

申请日：2019-07-24

申请人： Covestro Intellectual Property Gmbh & Co. Kg

发明人： Jens Langanke ,  Franz Beggel ,  Gernot Jaeger ,  Wolf Kloeckner ,  Volker Michele ,  Thomas Voessing

IPC分类号： C12P13/00 ,  C07C209/68 ,  C09B29/01

CPC分类号： C12P13/001 ,  C07C209/68 ,  C09B29/0003

摘要： The invention relates to a method for producing aniline or an aniline derivative, in which a solution of aminobenzoic acid in aniline with a mass fraction of aniline in the solution, in relation to the total mass of aminobenzoic acid and aniline, in the region of 20% to 85%, is subject to a thermal decarboxylation at a temperature in the region of 165° C. to 500° C. without the presence of a non-system catalyst, such that the aminobenzoic acid is converted into aniline. The obtained aniline can be converted into derivatives, such as di- and polyamines of the diphenylmethane series.

公开(公告)号：US11773053B2

公开(公告)日：2023-10-03

申请号：US16769845

申请日：2017-12-20

申请人： RHODIA OPERATIONS

发明人： Olivier Back ,  Bing Hong ,  Matthieu Guirardel

IPC分类号： C07C211/63 ,  C02F1/52 ,  C02F1/54 ,  C07C209/68

CPC分类号： C07C211/63 ,  C02F1/5272 ,  C02F1/547 ,  C07C209/68

摘要： The present invention concerns new cationic quaternary ammonium compounds which exhibit excellent adsorption properties on negatively charged surfaces. These ones can notably be obtained firstly by reacting an internal ketone with a twin-tail amine under reductive amination conditions to obtain a twin tail triamine, then subjecting the twin tail triamine to a quaternization reaction. They can also obtained be obtained by the quaternization reaction of a certain diamine.

公开(公告)号：US20230159432A1

公开(公告)日：2023-05-25

申请号：US17984705

申请日：2022-11-10

申请人： ENTEGRIS, INC.

发明人： Jonathan W. Dube ,  Christopher Brown ,  Keith Hao-Kiet Huynh ,  Hitendra Patel

IPC分类号： C07C209/86 ,  C07C209/68

CPC分类号： C07C209/86 ,  C07C209/68

摘要： The disclosure provides a process for preparing solid tri(C1-C4 alkyl)ammonium dihydrogen phosphates such as triethylammonium dihydrogen phosphate, in high yield, and in a free-flowing particulate form. The solid product advantageously possesses less than about 1500 ppm of aprotic organic solvents, less than about 1500 ppm of C1-C5 alkanols, and less than about 500 ppm of water, as determined by Karl Fischer titration.

公开(公告)号：US20230150919A1

公开(公告)日：2023-05-18

申请号：US17908197

申请日：2021-03-02

申请人： National University Corporation Hokkaido University

发明人： Hajime Ito ,  Koji Kubota

IPC分类号： C07C209/68 ,  C07C41/30 ,  C07C17/263 ,  C07C1/30 ,  C07C17/269 ,  C07D333/16 ,  C07D333/22 ,  C07D333/56 ,  C07C1/32

CPC分类号： C07C209/68 ,  C07C41/30 ,  C07C17/263 ,  C07C1/30 ,  C07C17/269 ,  C07D333/16 ,  C07D333/22 ,  C07D333/56 ,  C07C1/325

摘要： Disclosed is a method for producing a mono-cross-coupled aromatic compound (3-1) having one less leaving group than an aromatic compound (1) having at least two leaving groups, the method comprising: preparing the aromatic compound (1) having at least two leaving groups; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic boronic acid (2-1), an aromatic amino compound (2-2), a diboronic acid ester (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the aromatic compound (1) having at least two leaving groups with the compound (2) in the presence of a palladium catalyst and a base, in the absence of a solvent.

公开(公告)号：US20180258028A1

公开(公告)日：2018-09-13

申请号：US15759859

申请日：2016-09-28

申请人： OLON S.P.A.

发明人： Corrado COLLI ,  Alessandro AGOSTI ,  Stefano MAIORANA ,  Federica COLOMBO ,  Giorgio BERTOLINI

IPC分类号： C07C209/68 ,  C07C211/42 ,  C07D215/26

CPC分类号： C07C209/68 ,  C07C211/42 ,  C07C2602/08 ,  C07D215/26

摘要： Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.

公开(公告)号：US10000684B2

公开(公告)日：2018-06-19

申请号：US15466066

申请日：2017-03-22

申请人： CHINA UNIVERSITY OF PETROLEUM (BEIJING)

发明人： Guancheng Jiang ,  Shuanglei Peng ,  Yinbo He ,  Deli Gao ,  Lili Yang ,  Fan Liu ,  Xinliang Li ,  Zhengqiang Deng ,  Guangchang Ma ,  Li Zhao ,  Haifang Sun ,  Liexiang Han

IPC分类号： C09K8/32 ,  C07C209/68

CPC分类号： C09K8/32 ,  C07C209/68 ,  C09K8/03 ,  C09K2208/34 ,  C10M141/06 ,  C10M2201/041 ,  C10M2215/042

摘要： The present invention relates to the well drilling field in petroleum industry, in particular to a drilling fluid additive composition that contains a lubricant, an emulsifier, and a rheological modifier, wherein, the lubricant contains: graphite oxide and a biquaternary ammonium salt compound in which the cation part is represented by formula (1); the emulsifier is one or more of compounds represented by formula (I); the rheological modifier is a dimer acid-organic amine copolymer comprising structural units from dimer acid, structural units from alkylamine and structural units from arylamine. The present invention further provides an oil-based drilling fluid containing the composition and a use thereof. The oil-based drilling fluid containing the composition provided in the present invention obtains a lower lubrication coefficient, and favorable rheological property and thermostability, and is suitable for use in operation at a high temperature

公开(公告)号：US09956551B2

公开(公告)日：2018-05-01

申请号：US15158238

申请日：2016-05-18

申请人： Bruce H. Lipshutz ,  Sachin Handa

发明人： Bruce H. Lipshutz ,  Sachin Handa

IPC分类号： C07C45/68 ,  C07C41/30 ,  C07C209/32 ,  C07B37/04 ,  B01J31/06 ,  B01J35/00 ,  B01J35/12 ,  B01J31/02 ,  B01J23/89 ,  B01J37/16 ,  C07F9/12 ,  C07D471/04 ,  C07D409/04 ,  C07D405/14 ,  C07D405/04 ,  C07D403/04 ,  C07D401/04 ,  C07D333/60 ,  C07D317/22 ,  C07D317/46 ,  C07D241/18 ,  C07D239/26 ,  C07D239/54 ,  B01J31/24 ,  B01J31/22 ,  C07C201/12 ,  C07D211/70 ,  C07D213/30 ,  C07D213/64 ,  C07D215/06 ,  C07C269/08 ,  C07C209/68

CPC分类号： B01J31/2404 ,  B01J23/8906 ,  B01J31/0202 ,  B01J31/0209 ,  B01J31/068 ,  B01J31/22 ,  B01J35/0013 ,  B01J35/10 ,  B01J35/12 ,  B01J37/16 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2231/64 ,  B01J2531/004 ,  B01J2531/007 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/96 ,  B01J2531/985 ,  C07B37/04 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C201/12 ,  C07C205/12 ,  C07C209/325 ,  C07C209/68 ,  C07C211/45 ,  C07C269/06 ,  C07C269/08 ,  C07C319/20 ,  C07C2603/24 ,  C07D211/70 ,  C07D213/30 ,  C07D213/64 ,  C07D215/06 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D317/22 ,  C07D317/46 ,  C07D333/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07F9/12 ,  C07C271/28 ,  C07C321/28 ,  C07C43/215 ,  C07C43/205 ,  C07C43/2055 ,  C07C47/546 ,  C07C47/575 ,  C07C39/21

摘要： In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.

公开(公告)号：US09905769B2

公开(公告)日：2018-02-27

申请号：US15245939

申请日：2016-08-24

申请人： PHILLIPS 66 COMPANY

发明人： Joseph Bullock ,  Brian Worfolk

IPC分类号： C07C69/76 ,  H01L51/00 ,  C07C213/02 ,  C07C213/08 ,  C07C219/10 ,  H01L51/42

CPC分类号： H01L51/0047 ,  C07C209/12 ,  C07C209/68 ,  C07C213/02 ,  C07C213/06 ,  C07C213/08 ,  C07C219/10 ,  C07C2604/00 ,  H01L51/0003 ,  H01L51/4253 ,  C07C219/14 ,  C07C211/63

摘要： A process of dissolving [6,6]-phenyl-C60-butyric-N-2-dimethylaminoethyl ester in a solvent to produce a first mixture. A reagent is added to the first mixture to produce a second mixture. The second mixture is then refluxed to produce [6,6]-phenyl-C60-butyric-N-2-trimethylammonium ethyl ester iodide.