公开(公告)号：US20200024244A1

公开(公告)日：2020-01-23

申请号：US16482100

申请日：2018-02-07

Applicant: BASF SE

Inventor： Abhijeet Roy ,  Dominik Ohlmann ,  Rahul Mulay ,  Priti Kulkarni ,  Vijay Narayanan Swaminathan

IPC: C07D307/33

Abstract: A process for preparing D-glucaro-6,3-lactone from a salt of D-glucaric acid is provided. The process includes: adding a mineral acid to a pre-cooled solution including a salt of D-glucaric acid, water, and acetone to obtain a crude mixture; allowing the crude mixture to rise to a temperature in a range of ≥15° C. to ≤35° C. and stirring the crude mixture; filtrating the crude mixture and washing with an acetone and water solvent mixture to obtain a filtrate; concentrating the filtrate under vacuum pressure to obtain a concentrated filtrate having a water content in a range of ≥20.0 wt. % to ≤40.0 wt. %, relative to an overall weight of the concentrated filtrate; storing the concentrated filtrate at a temperature in a range of ≥0° C. to ≤5° C., and optionally repeating the concentrating and storing steps to obtain a precipitate comprising D-glucaro-6,3-lactone.

公开(公告)号：US20210139442A1

公开(公告)日：2021-05-13

申请号：US17047893

申请日：2019-04-11

Applicant: BASF SE

Inventor： Dominik Ohlmann ,  Abhijeet Roy ,  Boris Tissberger ,  Thomas Bodenstein ,  Rahul Mulay

IPC: C07D307/33

Abstract: Described herein are D-glucaro-6,3-lactone monoester products and a novel process for the preparation of the same.

公开(公告)号：US10774058B2

公开(公告)日：2020-09-15

申请号：US16482100

申请日：2018-02-07

Applicant: BASF SE

Inventor： Abhijeet Roy ,  Dominik Ohlmann ,  Rahul Mulay ,  Priti Kulkarni ,  Vijay Narayanan Swaminathan

IPC: C07D307/33

Abstract: A process for preparing D-glucaro-6,3-lactone from a salt of D-glucaric acid is provided. The process includes: adding a mineral acid to a pre-cooled solution including a salt of D-glucaric acid, water, and acetone to obtain a crude mixture; allowing the crude mixture to rise to a temperature in a range of ≥15° C. to ≤35° C. and stirring the crude mixture; filtrating the crude mixture and washing with an acetone and water solvent mixture to obtain a filtrate; concentrating the filtrate under vacuum pressure to obtain a concentrated filtrate having a water content in a range of ≥20.0 wt. % to ≤40.0 wt. %, relative to an overall weight of the concentrated filtrate; storing the concentrated filtrate at a temperature in a range of ≥0° C. to ≤5° C., and optionally repeating the concentrating and storing steps to obtain a precipitate comprising D-glucaro-6,3-lactone.