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公开(公告)号：US11046961B2
公开(公告)日：2021-06-29
申请号：US16700322
申请日：2019-12-02
Applicant: BASF SE
Inventor： Christian Degering , Thorsten Eggert , Stefan Evers , Karl-Heinz Maurer , Johannes Bongaerts
Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
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公开(公告)号：US20200095564A1
公开(公告)日：2020-03-26
申请号：US16700322
申请日：2019-12-02
Applicant: BASF SE
Inventor： Christian Degering , Thorsten Eggert , Stefan Evers , Karl-Heinz Maure , Johannes Bongaerts
Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
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公开(公告)号：US20180073005A1
公开(公告)日：2018-03-15
申请号：US15712652
申请日：2017-09-22
Applicant: BASF SE
Inventor： Christian Degering , Thorsten Eggert , Stefan Evers , Karl-Heinz Maurer , Johannes Bongaerts
CPC classification number: C12N9/50 , C12N15/625 , C12N15/70 , C12N15/75
Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
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