公开(公告)号：US3796704A

公开(公告)日：1974-03-12

申请号：US17220171

申请日：1971-08-16

Applicant: BAYER AG

Inventor： METZGER CARL ,  MEISER WERNER ,  BUECHEL KARL HEINZ ,  PLEMPEL MANFRED

IPC: A01N43/50 ,  A61K31/415 ,  A61P31/04 ,  C07D233/56 ,  C07D233/60 ,  C07D233/62 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: PHENYL-IMIDAZOLYLALKANYL DERIVATIVES ARE ANTIMYCOTIC AGENTS. THEY ARE PREPARED BY A NUMBER OF PROCESSES INCLUDING ACYLATION OR SULFONYLATION OF A PHENYL-IMIDAZOLYLALKANOL, TREATMENT OF A PHENYL-ALKANYL-CARBINOL WITH A DIIMIDAZOLLYL SULFONE, OXIDATION OF A PHENYL-IMIDAZOLYLALKYLMERCAPTAN OR REDUCTION OF A PHENYL-IMIDAZOLYLALKYLANOTE OR ALKANONITRILE. A TYPICAL EMBODIMENT IS 1-(1,1-DIPHENYL-2-ACETOXYETHYL) IMIDAZOLE.

公开(公告)号：US3892764A

公开(公告)日：1975-07-01

申请号：US34693973

申请日：1973-04-02

Applicant: BAYER AG

Inventor： METZGER CARL ,  MEISER WERNER ,  BUECHEL KARL HEINZ ,  PLEMPEL MANFRED

IPC: C07D521/00 ,  C07D49/36

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Phenyl-imidazolylalkanyl derivatives are antimycotic agents. They are prepared by a number of processes including acylation or sulfonylation of a phenyl-imidazolylalkanol, treatment of a phenyl-alkanyl-carbinol with a diimidazolyl sulfone, oxidation of a phenyl-imidazolylalkylmercaptan or reduction of a phenylimidazolylalkanoate or alkanonitrile. A typical embodiment is 1(1,1-diphenyl-2-acetoxyethyl)imidazole.

Abstract translation: 苯基 - 咪唑烷基烷基衍生物是抗真菌剂。 它们通过许多方法制备，包括苯基 - 咪唑基烷醇的酰化或磺酰化，用二咪唑基砜处理苯基 - 烷基 - 甲醇，氧化苯基 - 咪唑烷基硫醇或还原苯基 - 咪唑烷基链烷酸酯或链烷腈。 典型的实施方案是1-（1,1-二苯基-2-乙酰氧基乙基）咪唑。