公开(公告)号：US3900488A

公开(公告)日：1975-08-19

申请号：US30857672

申请日：1972-11-21

Applicant: BAYER AG

Inventor： HUPER FRITZ

IPC: C07D499/42 ,  C12N11/08 ,  C12P37/06

CPC classification number: C12P37/06 ,  C12N11/08

Abstract: An extremely important major industrial advance in the field of manufacture of 6-aminopenicillanic acid is disclosed which involves contacting a penicillin and a water-insoluble polymeric carrier-bound penicillin acylase with the concommitant production of 6-aminopenicillanic acid.

公开(公告)号：US3871964A

公开(公告)日：1975-03-18

申请号：US34545273

申请日：1973-03-27

Applicant: BAYER AG

Inventor： HUPER FRITZ ,  RAUENBUSCH ERICH ,  SCHMIDT-KASTNER GUNTER ,  BOMER BRUNO ,  BARTL HERBERT

IPC: A61K38/46 ,  C07K17/08 ,  C08F8/00 ,  C08F8/30 ,  C08F20/20 ,  C12N11/08 ,  C07G7/02

CPC classification number: C12N11/08 ,  C08F8/00 ,  C08F20/20 ,  C08F20/02

Abstract: Polypeptide materials such as enzymes are rendered waterinsoluble by bonding to a cross-linked copolymer produced by copolymerizing of (A) about 0.1 to 30 wt. % of at least one Alpha , Beta -monoolefinically unsaturated dicarboxylic acid anhydride having about 4 to 9 carbon atoms; (B) about 35 to 90 wt % of at least one di-and/or poly(meth)acrylate of a dial and/or polyol; and (C) about 5 to 60 wt % of at least one hydrophilic monomer.

Abstract translation: 通过与（A）约0.1〜30重量％的共聚而制成的交联共聚物结合，使多肽材料如酶变得不溶于水。 ％的至少一种具有约4至9个碳原子的α，β-单烯属不饱和二羧酸酐; （B）约35至90重量％的至少一种表面和/或多元醇的二 - 和/或聚（甲基）丙烯酸酯; 和（C）约5至60重量％的至少一种亲水性单体。

公开(公告)号：US3897409A

公开(公告)日：1975-07-29

申请号：US32710873

申请日：1973-01-26

Applicant: BAYER AG

Inventor： HUPER FRITZ ,  SCHMIDT-KASTNER GUNTHER

IPC: A61K9/00 ,  A61K9/08 ,  A61K31/43 ,  A61K38/00 ,  B01D9/02 ,  B01D9/04 ,  B01D19/04 ,  C07D499/42 ,  C12N9/00 ,  C12N9/64 ,  C07C103/52

CPC classification number: A61K9/0019 ,  A61K9/08 ,  A61K31/43 ,  A61K38/4853 ,  A61K38/55 ,  B01D9/04 ,  B01D19/04 ,  C12N9/00 ,  C12N9/6445

Abstract: The disclosure relates to a novel process for the freeze concentration of aqueous solutions of heat-labile substances which includes the steps of cooling a crude aqueous solution of heat-labile substance to produce a frozen crude solution and a pre-cooled crude solution of said heat-labile substance, mixing said frozen crude solution and said pre-cooled solution with ice, to produce pure ice crystals and a first concentrated solution of said heat-labile substance and subsequently separating said pure ice crystals from said first concentrated solution of said heatlabile substance. The disclosure further describes the additional steps of further cooling said first concentrated solution to form further ice crystals and a second concentrated solution of said heat-labile substance and subsequently separating said further ice crystals from said second concentrated solution of said heatlabile substance.

Abstract translation: 本发明涉及一种热不稳定物质的水溶液的冷冻浓缩的新方法，其包括冷却热不稳定物质的粗制水溶液以产生冷冻粗溶液的步骤和所述热量的预冷粗制溶液 将所述冷冻粗溶液和所述预冷却溶液与冰混合，以产生纯冰晶体和所述热不稳定物质的第一浓缩溶液，随后将所述纯冰晶与所述第一浓缩溶液分离， 不稳定物质。 本公开进一步描述了进一步冷却所述第一浓缩溶液以形成另外的冰晶和所述热不稳定物质的第二浓缩溶液并随后从所述热不稳定物质的所述第二浓缩溶液中分离出所述另外的冰晶的附加步骤。

公开(公告)号：US3926730A

公开(公告)日：1975-12-16

申请号：US44372374

申请日：1974-02-19

Applicant: BAYER AG

Inventor： HUPER FRITZ ,  RAUENBUSCH ERICH

IPC: C12N9/26 ,  C07G7/02

CPC classification number: C12N9/2414 ,  Y02P20/582 ,  Y10S435/815

Abstract: Alpha -Amylase is separated from a liquid which contains Alpha -amylase and foreign protein impurities according to a process which comprises adsorbing the Alpha -amylase from the liquid onto a carrier-bound Alpha -amylase inhibitor to form an enzyme inhibitor complex and separating the complex from the liquid. Purified Alpha -amylase substantially free from foreign protein impurities may be obtained by washing the complex and desorbing the Alpha -amylase from the carrier-bound inhibitor.

公开(公告)号：US3910825A

公开(公告)日：1975-10-07

申请号：US34579273

申请日：1973-03-28

Applicant: BAYER AG

Inventor： HUPER FRITZ ,  RAUENBUSCH ERICH ,  SCHMIDT-KASTNER GUNTER ,  BOMER BRUNO ,  BARTL HERBERT

IPC: C08F222/04 ,  C07D499/42 ,  C08F8/00 ,  C08F20/20 ,  C12N11/08 ,  C12B1/00 ,  C07G7/02 ,  C12D13/02

CPC classification number: C12N11/08 ,  C08F8/00 ,  C08F20/20 ,  Y10S530/816 ,  C08F20/02

Abstract: Peptide materials such as enzymes and enzyme inhibitors are rendered water-insoluble by binding the peptide materials to a cross-linked copolymer formed by copolymerizing the following units: (A) about 0.1 to 50 weight percent of at least one Alpha , Beta -monoolefinically unsaturated dicarboxylic acid anhydride having about 4 to 9 carbon atoms and (B) about 99.9 to 50 weight percent of at least one di- and/or poly(meth) acrylate of a diol and/or a polyol.

Abstract translation: 肽材料如酶和酶抑制剂通过将肽材料与通过共聚以下单元形成的交联共聚物结合而变成水不溶性：（A）约0.1至50重量％的至少一种α，β-单烯属不饱和 具有约4至9个碳原子的二羧酸酐和（B）约99.9至50重量％的二醇和/或多元醇的至少一种二 - 和/或聚（甲基）丙烯酸酯。