公开(公告)号：US3531488A

公开(公告)日：1970-09-29

申请号：US3531488D

申请日：1967-05-05

Applicant: BAYER AG

Inventor： WOLLWEBER HARTMUND ,  HORSTMANN HARALD ,  MENG KARL

IPC: C07D207/26 ,  C07D211/02 ,  C07D211/76 ,  C07D211/78 ,  C07D27/08

CPC classification number: C07D207/26 ,  C07D211/02 ,  C07D211/76 ,  C07D211/78 ,  Y10S514/929 ,  Y10S514/962

公开(公告)号：US3629442A

公开(公告)日：1971-12-21

申请号：US3629442D

申请日：1969-05-29

Applicant: BAYER AG

Inventor： HORSTMANN HARALD ,  WOLLWEBER HARTMUND ,  MENG KARL

IPC: C07D307/33 ,  A61K27/00

CPC classification number: C07D307/33

Abstract: PHARMACEUTICAL COMPOSITIONS ARE PRODUCED WHICH COMPRISE A COMPOUND OF THE FORMULA:

R IS HYDROGEN OR METHYL; R'' IS HYDROGEN OR LOWER ALKYL. R" IS HYDROGEN OR LOWER ALKYL; AND N IS 0 OR 1; OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF, IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE INERT DILUENT OR CARRIER. THESE COMPOSITIONS ARE USEFUL FOR THEIR SALURETIC EFFECT AND ARE USEFUL IN TREATING EDEMA AND HYPERTENSION.

WHEREIN:

N(-R)-O2S-)BENZENE (VII) WITH R'' ATTACHED AS IN III

1-(H2N-O2S-),2-CL,5-(HOOC-CH(-R")-(CH2)N-CH2-CH(-OH)-CH2-

CH2-N(-R)-O2S-)BENZENE (III)

1-(H2N-O2S-),2-CL,5-((-CH2-(CH2)N-CH(-R")-CO-O-)(-R'')>CH2-

公开(公告)号：US3897488A

公开(公告)日：1975-07-29

申请号：US43274474

申请日：1974-01-11

Applicant: BAYER AG

Inventor： HORSTMANN HARALD ,  WOLLWEBER HARTMUND ,  MENG KARL

IPC: C07D207/08 ,  C07C143/40

CPC classification number: C07D207/08

Abstract: Pharmaceutical compositions are produced which comprise a compound of the formula:

WHEREIN: R is hydrogen or methyl; R'' is hydrogen or lower alkyl; R'''' is hydrogen or lower alkyl; and N IS 0 OR 1; OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF, IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE INERT DILUENT OR CARRIER. These compositions are useful for their saluretic effect and are useful in treating edema and hypertension.

Abstract translation: 制备药物组合物，其包含下式的化合物：

公开(公告)号：US3499005A

公开(公告)日：1970-03-03

申请号：US3499005D

申请日：1967-06-06

Applicant: BAYER AG

Inventor： HORSTMANN HARALD ,  WOLLWEBER HARTMUND ,  MENG KARL

IPC: C07D307/33 ,  C07D5/04 ,  A01N9/16

CPC classification number: C07D307/33