公开(公告)号：US20170210738A1

公开(公告)日：2017-07-27

申请号：US15328455

申请日：2015-07-22

申请人： Bayer Pharma Aktiengesellschaft

发明人： Bernd BUCHMANN ,  Iring HEISLER ,  Thomas MÜLLER ,  Arwed CLEVE ,  Melanie HEROULT ,  Roland NEUHAUS ,  Heike PETRUL ,  Maria QUANZ-SCHÖFFEL

IPC分类号： C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D401/12 ,  A61K31/4709

CPC分类号： C07D417/14 ,  A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14

摘要： The present invention relates to chemical compounds of formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

公开(公告)号：US20170226081A1

公开(公告)日：2017-08-10

申请号：US15328463

申请日：2015-07-22

申请人： Bayer Pharma Aktiengesellschaft

发明人： Bernd BUCHMANN ,  Iring HEISLER ,  Thomas MÜLLER ,  Arwed CLEVE ,  Mélanie HÉROULT ,  Roland NEUHAUS ,  Heike PETRUL ,  Maria QUANZ-SCHÖFFEL

IPC分类号： C07D401/12 ,  C07D417/14 ,  C07D413/14 ,  A61K31/4709 ,  C07D401/14

CPC分类号： C07D401/12 ,  A61K31/136 ,  A61K31/337 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/555 ,  A61K31/573 ,  A61K31/675 ,  A61K31/704 ,  C07D215/50 ,  C07D231/38 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  A61K2300/00

摘要： The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

公开(公告)号：US20170037028A1

公开(公告)日：2017-02-09

申请号：US15106814

申请日：2014-12-16

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Iring HEISLER ,  Thomas MÜLLER ,  Holger SIEBENEICHER ,  Bernd BUCHMANN ,  Arwed CLEVE ,  Judith GÜNTHER ,  Marcus KOPPITZ ,  Melanie HEROULT ,  Roland NEUHAUS ,  Heike PETRUL ,  Maria QUANZ-SCHÖFFEL

IPC分类号： C07D401/12 ,  A61K31/473 ,  C07D401/14 ,  A61K31/5377 ,  C07D471/04 ,  C07D413/14 ,  C07D417/14 ,  C07D495/10 ,  C07D405/14 ,  A61K31/496 ,  A61K31/4709 ,  C07D409/14

CPC分类号： C07D401/12 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/496 ,  A61K31/5377 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/10

摘要： The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

摘要翻译： 本发明涉及选择性抑制葡萄糖转运蛋白1（GLUT1）的化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合，用于制备药物组合物的用途，用于治疗或预防 疾病，以及可用于制备所述化合物的中间体化合物。