公开(公告)号：US20210221798A1

公开(公告)日：2021-07-22

申请号：US17218907

申请日：2021-03-31

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC分类号： C07D403/14 ,  A61K49/10 ,  C07D257/02

摘要： The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20200283420A1

公开(公告)日：2020-09-10

申请号：US16463076

申请日：2017-11-24

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Markus BERGER ,  Jessica LOHRKE ,  Christoph-Stephan HILGER ,  Gregor JOST ,  Thomas FRENZEL ,  Olaf PANKNIN ,  Hubertus PIETSCH

IPC分类号： C07D403/14 ,  A61K49/10 ,  C07D257/02

摘要： The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

公开(公告)号：US20220008562A1

公开(公告)日：2022-01-13

申请号：US17295647

申请日：2019-11-21

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Stephan HOLZSCHUH ,  Thomas FRENZEL ,  Gregor JOST ,  Jessica LOHRKE ,  Wolfgang EBERT ,  Thomas BRUMBY ,  Wolfgang HALFBRODT

IPC分类号： A61K49/10 ,  A61K49/08 ,  A61K49/12

摘要： The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.