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1.发明申请(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use 有权（氮杂）吡唑并吡咯并嘧啶酮和吲唑并嘧啶酮及其用途公开(公告)号：US20150126449A1
公开(公告)日：2015-05-07
申请号：US14533915
申请日：2014-11-05
发明人： Jorma Haßfeld , Tom KINZEL , Johannes Köbberling , Yolanda CANCHO GRANDE , Kristin BEYER , Susanne Röhrig , Maria Köllnberger , Michael SPERZEL , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Manuel ELLERMANN
IPC分类号： C07D487/04 , C07D471/14 , A61K45/06 , A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/12
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
摘要翻译： 本申请涉及新的取代的（氮杂）吡啶并吡咯并嘧啶酮和吲唑并嘧啶酮，其制备方法，单独使用的化合物或用于治疗和/或预防疾病，特别是用于治疗和/或预防的方法中的组合 具有或不具有潜在遗传性或获得性出血性疾病的患者的急性和复发性出血，其中所述出血与选自月经过多，产后出血，出血性休克，创伤，手术，移植，中风， 肝脏疾病，遗传性血管性水肿，流鼻血和关节炎后的滑膜炎和软骨损伤。
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公开(公告)号：US20210252161A1
公开(公告)日：2021-08-19
申请号：US17166713
申请日：2021-02-03
发明人： Hans-Georg LERCHEN , Yolanda CANCHO GRANDE , Beatrix STELTE-LUDWIG , Anette SOMMER , Christoph MAHLERT , Anne-Sophie REBSTOCK , Simone GREVEN , Nils GRIEBENOW , Jan TEBBE , Oliver KENSCH
摘要： The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20190262463A1
公开(公告)日：2019-08-29
申请号：US15739130
申请日：2016-06-20
发明人： Hans-Georg LERCHEN , Yolanda CANCHO GRANDE , Beatrix STELTE-LUDWIG , Anette SOMMER , Christoph MAHLERT , Anne-Sophie REBSTOCK , Simone GREVEN , Nils GRIEBENOW , Jan TEBBE , Oliver KENSCH
摘要： The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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4.发明申请公开(公告)号：US20180318438A1
公开(公告)日：2018-11-08
申请号：US15739136
申请日：2016-06-20
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Yolanda CANCHO GRANDE , Sven WITTROCK , Beatrix STELTE-LUDWIG , Stephan MÄRSCH , Uwe GRITZAN , Christoph MAHLERT , Simone GREVEN , Anette SOMMER , Sandra BERNDT , Lisa DIETZ
IPC分类号： A61K47/68 , C07K16/28 , A61K31/40 , A61K31/4025 , A61P35/00
CPC分类号： A61K47/6803 , A61K31/40 , A61K31/4025 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K2039/505 , A61K2039/572 , A61P35/00 , C07K16/2878 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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5.发明申请公开(公告)号：US20190330357A1
公开(公告)日：2019-10-31
申请号：US16310285
申请日：2017-06-08
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Yolanda CANCHO GRANDE , Sven WITTROCK , Beatrix STELTE-LUDWIG , Dennis KIRCHHOFF , Christoph MAHLERT , Simone GREVEN , Stephan MÄRSCH
摘要： The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti-CD 123-antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20170260226A1
公开(公告)日：2017-09-14
申请号：US15510348
申请日：2015-09-07
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06 , C07J31/003 , C07J41/0038
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
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7.发明申请2,5-DISUBSTITUTED CYCLOPENTANECARBOXYLIC ACIDS AND THEIR USE 审中-公开2,5-DISUBSTITUTED CYPOPENTANECARBOXYLIC ACIDS AND THEE USE公开(公告)号：US20170022171A1
公开(公告)日：2017-01-26
申请号：US15301392
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC分类号： C07D253/08 , A61K31/53 , C07D413/12 , A61K45/06
CPC分类号： C07D253/08 , A61K31/53 , A61K45/06 , C07D413/12
摘要： The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
摘要翻译： 本申请涉及新的2,5-二取代的环戊烷羧酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/ 或预防疾病，特别是用于治疗和/或预防呼吸，肺和心血管疾病。
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8.发明公开公开(公告)号：US20230399411A1
公开(公告)日：2023-12-14
申请号：US18336769
申请日：2023-06-16
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Yolanda CANCHO GRANDE , Sven WITTROCK , Beatrix STELTE-LUDWIG , Dennis KIRCHHOFF , Christoph MAHLERT , Simone GREVEN , Stephan MÄRSCH
CPC分类号： C07K16/2866 , A61K47/6851 , A61K47/6803 , A61K47/6849 , A61P35/00 , A61K31/40
摘要： The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20230039341A1
公开(公告)日：2023-02-09
申请号：US17374756
申请日：2021-07-13
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Yolanda CANCHO GRANDE , Leo MARX , Beatrix STELTE-LUDWIG , Carsten TERJUNG , Christoph MAHLERT , Simone GREVEN , Anette SOMMER , Sandra BERNDT
IPC分类号： A61K47/68 , A61K47/65 , A61K31/4025 , A61K31/4439
摘要： The present invention relates to novel binder-prodrug conjugates (APDCs) where binders are conjugated with inactive precursor compounds of kinesin spindle protein inhibitors, and to antibody-drug conjugates ADCs and to processes for producing these APDCs and ADCs.
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10.发明申请公开(公告)号：US20180169256A1
公开(公告)日：2018-06-21
申请号：US15739111
申请日：2016-06-20
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Yolanda CANCHO GRANDE , Leo MARX , Beatrix STELTE-LUDWIG , Carsten TERJUNG , Christoph MAHLERT , Simone GREVEN , Anette SOMMER , Sandra BERNDT
IPC分类号： A61K47/68 , A61K47/65 , A61K31/4025 , A61K31/4439
CPC分类号： A61K47/6803 , A61K31/4025 , A61K31/4439 , A61K47/65 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K2300/00
摘要： The present invention relates to novel binder-prodrug conjugates (APDCs) where binders are conjugated with inactive precursor compounds of kinesin spindle protein inhibitors, and to antibody-drug conjugates ADCs and to processes for producing these APDCs and ADCs.
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