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公开(公告)号：US20170313665A1
公开(公告)日：2017-11-02
申请号：US15523061
申请日：2015-10-30
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KÖLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
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2.发明申请ANTIBODY DRUG CONJUGATES (ADCS) WITH KINESIN SPINDEL PROTEIN (KSP) 有权抗生素药物（ADCS）与KINESIN Spindel蛋白（KSP）公开(公告)号：US20160346402A1
公开(公告)日：2016-12-01
申请号：US15105486
申请日：2014-12-10
发明人： Hans-Georg LERCHEN , Sven WITTROCK , Nils GRIEBENOW , Beatrix STELTE-LUDWIG , Anette SOMMER , Sandra BERNDT , Christoph MAHLERT , Mario LOBELL , Carsten TERJUNG , Simone GREVEN , Yolanda CANCHO GRANDE
IPC分类号： A61K47/48 , C07D233/64 , C07D403/12 , C07K5/062 , C07D207/337 , C07D403/14 , C07C53/18 , C07K16/32 , C07D231/12 , C07K16/28 , C07K5/107
CPC分类号： A61K47/6851 , A61K47/6803 , A61K47/6811 , A61K47/6849 , C07C53/18 , C07D207/335 , C07D207/337 , C07D231/12 , C07D233/64 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07K5/06052 , C07K5/1016 , C07K16/2863 , C07K16/2875 , C07K16/32 , C07K2317/24 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present application relates to novel antibody drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及新型抗体药物偶联物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC用于治疗和/或预防疾病，以及使用这些ADC 制备用于治疗和/或预防疾病的药物，特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法进行，也可以与其他药物组合进行或进一步的治疗措施。
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公开(公告)号：US20150274754A1
公开(公告)日：2015-10-01
申请号：US14738148
申请日：2015-06-12
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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4.发明申请公开(公告)号：US20170145058A1
公开(公告)日：2017-05-25
申请号：US15309991
申请日：2015-05-05
发明人： Nils GRIEBENOW , Stefan BRÄSE , Alicia DILMAC
CPC分类号： C07K7/64 , A61K38/00 , A61K47/60 , A61K47/68 , A61K47/6803 , C07K16/00 , C07K2317/55
摘要： The present application relates to a novel process for the targeted conjugation of peptides and proteins which is characterized by the pairwise C2-bridging of cysteine amino acids via their thiol groups, furthermore to the conjugates of peptides and proteins which can be obtained by such a process and also to the use of such conjugates for the diagnosis and/or treatment of disorders.
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公开(公告)号：US20210252161A1
公开(公告)日：2021-08-19
申请号：US17166713
申请日：2021-02-03
发明人： Hans-Georg LERCHEN , Yolanda CANCHO GRANDE , Beatrix STELTE-LUDWIG , Anette SOMMER , Christoph MAHLERT , Anne-Sophie REBSTOCK , Simone GREVEN , Nils GRIEBENOW , Jan TEBBE , Oliver KENSCH
摘要： The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20190262463A1
公开(公告)日：2019-08-29
申请号：US15739130
申请日：2016-06-20
发明人： Hans-Georg LERCHEN , Yolanda CANCHO GRANDE , Beatrix STELTE-LUDWIG , Anette SOMMER , Christoph MAHLERT , Anne-Sophie REBSTOCK , Simone GREVEN , Nils GRIEBENOW , Jan TEBBE , Oliver KENSCH
摘要： The invention relates to site specific homogeneous binder drug conjugates of kinesin spindle protein inhibitors, to active metabolites of these conjugates, to processes for preparing these conjugates, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20170204137A1
公开(公告)日：2017-07-20
申请号：US15472476
申请日：2017-03-29
发明人： Ingo FLAMME , Johannes KÖBBERLING , Hans-Georg LERCHEN , Nils GRIEBENOW , Rudolf SCHOHE-LOOP , Sven WITTROCK , Maria KÖLLNBERGER , Frank WUNDER , Gorden REDLICH , Andreas KNORR , Julie MARLEY , Iain PRITCHARD
IPC分类号： C07K5/062
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20210253557A1
公开(公告)日：2021-08-19
申请号：US16758741
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG , Nils GRIEBENOW
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D403/06 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
摘要翻译： 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
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