公开(公告)号：US20180344739A1

公开(公告)日：2018-12-06

申请号：US16101250

申请日：2018-08-10

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Jorma HAßFELD ,  Tom KINZEL ,  Johannes KÖBBERLING ,  Yolanda CANCHO-GRANDE ,  Kristin BEYER ,  Susanne RÖHRIG ,  Maria KÖLLNBERGER ,  Michael SPERZEL ,  Nils BURKHARDT ,  Karl-Heinz SCHLEMMER ,  Christian STEGMANN ,  Joachim SCHUHMACHER ,  Matthias WERNER ,  Manuel ELLERMANN

IPC分类号： A61K31/519 ,  C07D487/12 ,  A61K45/06 ,  C07D487/04 ,  C07D471/14

摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

公开(公告)号：US20180318437A1

公开(公告)日：2018-11-08

申请号：US15739134

申请日：2016-06-20

申请人： Bayer Pharma Aktiengesellschaft

发明人： Hans-Georg LERCHEN ,  Anne-Sophie REBSTOCK ,  Yolanda CANCHO-GRANDE ,  Sven WITTROCK ,  Beatrix STELTE-LUDWIG ,  Christoph MAHLERT ,  Simone GREVEN ,  Stephan MÄRSCH ,  Dennis KIRCHHOFF

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K31/40 ,  A61K31/4025 ,  A61P35/00

摘要： The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

公开(公告)号：US20170239251A1

公开(公告)日：2017-08-24

申请号：US15416651

申请日：2017-01-26

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Jorma HAßFELD ,  Tom KINZEL ,  Johannes KÖBBERLING ,  Yolanda CANCHO-GRANDE ,  Kristin BEYER ,  Susanne RÖHRIG ,  Maria KÖLLNBERGER ,  Michael SPERZEL ,  Nils BURKHARDT ,  Karl-Heinz SCHLEMMER ,  Christian STEGMANN ,  Joachim SCHUHMACHER ,  Matthias WERNER ,  Manuel ELLERMANN

IPC分类号： A61K31/519

CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D471/14 ,  C07D487/04 ,  C07D487/12

摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.