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公开(公告)号：US20180344739A1
公开(公告)日：2018-12-06
申请号：US16101250
申请日：2018-08-10
发明人： Jorma HAßFELD , Tom KINZEL , Johannes KÖBBERLING , Yolanda CANCHO-GRANDE , Kristin BEYER , Susanne RÖHRIG , Maria KÖLLNBERGER , Michael SPERZEL , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Manuel ELLERMANN
IPC分类号： A61K31/519 , C07D487/12 , A61K45/06 , C07D487/04 , C07D471/14
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US20180022780A1
公开(公告)日：2018-01-25
申请号：US15514456
申请日：2015-09-24
发明人： Donald BIERER , Ingo FLAMME , Johannes KÖBBERLING , Bernd RIEDL , Annette BECK-SICKINGER , Ria SCHOENAUER , Jan-Patrick FISCHER
CPC分类号： C07K14/001 , A61K38/00 , A61K38/16 , A61K38/55 , C07K14/575 , C07K2319/30 , C07K2319/31
摘要： The invention relates to novel, biologically active, stabilized Adrenomedullin (ADM) compounds. The invention further relates to the compounds for use in a method for the treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, and to medicaments comprising the compounds for treatment and/or prevention of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20170334917A1
公开(公告)日：2017-11-23
申请号：US15523954
申请日：2015-10-30
发明人： Manuel ELLERMANN , Gaelle VALOT , Yolanda CANCHO GRANDE , Jorma HAßFELD , Tom KINZEL , Johannes KÖBBERLING , Kristin BEYER , Susanne RÖHRIG , Michael SPERZEL , Jan STAMPFUß , Imke MEYER , Maria KÖLLNBERGER , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Jörg HEIERMANN , Willem Jan HENGEVELD
IPC分类号： C07D487/04 , C07D403/14 , C07D271/10 , C07D271/06 , C07D247/02 , C07D231/00 , C07D211/06 , C07D471/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D211/06 , C07D231/00 , C07D247/02 , C07D271/06 , C07D271/10 , C07D403/14 , C07D471/04
摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US20170239251A1
公开(公告)日：2017-08-24
申请号：US15416651
申请日：2017-01-26
发明人： Jorma HAßFELD , Tom KINZEL , Johannes KÖBBERLING , Yolanda CANCHO-GRANDE , Kristin BEYER , Susanne RÖHRIG , Maria KÖLLNBERGER , Michael SPERZEL , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Manuel ELLERMANN
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/12
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US20170204137A1
公开(公告)日：2017-07-20
申请号：US15472476
申请日：2017-03-29
发明人： Ingo FLAMME , Johannes KÖBBERLING , Hans-Georg LERCHEN , Nils GRIEBENOW , Rudolf SCHOHE-LOOP , Sven WITTROCK , Maria KÖLLNBERGER , Frank WUNDER , Gorden REDLICH , Andreas KNORR , Julie MARLEY , Iain PRITCHARD
IPC分类号： C07K5/062
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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