公开(公告)号：US20190177391A1

公开(公告)日：2019-06-13

申请号：US16089128

申请日：2017-03-29

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Shuyuan CHEN ,  Paul A. GRAYBURN

IPC: C07K14/575 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C12N15/85 ,  A61K48/00 ,  A61K41/00 ,  A61K47/69

Abstract: Embodiments of the disclosure concern methods and compositions for treatment of a cardiac-related medical condition. In particular embodiments, ANGPTL8 is provided to an individual in need thereof for the treatment or prevention of a cardiac-related medical condition. In certain cases, ANGPTL8 is provided to an individual with cardiomyopathy, such as Adriamycin-induced cardiomyopathy, using ultrasound-targeted microbubble destruction.