公开(公告)号：US20240165272A1

公开(公告)日：2024-05-23

申请号：US18092300

申请日：2022-12-31

Applicant: BEIJING UNIVERSITY OF TECHNOLOGY

Inventor： Dongdong SU ,  Yong ZHANG

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61K49/0002 ,  A61B5/0095 ,  A61B5/14556

Abstract: A liver-targeted fluorescence/photoacoustic dual-modal probe for the early detection of drug-induced hepatic inflammation and autoimmune hepatitis is disclosed. The chemical makeup of the probe hCy-Tf-CA is shown in Equation 1. The fluorescence and photoacoustic signal of probe-only solution is very weak, the dual-modal signal was significantly increased after selectively reacting with O2·−. The probe has the advantages of early preparation, live-targeting ability, high selectivity and sensitivity and dual-modal imaging. The probe can in situ visualization of O2·− in early hepatic inflammation with fluorescent/photoacoustic dual-modal imaging, providing a potential strategy in biomedical field with broad application prospects.