公开(公告)号：US12082938B2

公开(公告)日：2024-09-10

申请号：US17533278

申请日：2021-11-23

Applicant: Barbara Smith ,  Christopher Miranda

Inventor： Barbara Smith ,  Christopher Miranda

IPC: A61B5/00 ,  G01N15/10 ,  G01N15/01

CPC classification number: A61B5/4064 ,  A61B5/0095 ,  G01N15/1023 ,  G01N15/01 ,  G01N2015/1006

Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

公开(公告)号：US12078724B2

公开(公告)日：2024-09-03

申请号：US17746530

申请日：2022-05-17

Applicant: CIlag GmbH International

Inventor： Charles J. Scheib ,  Joshua D. Young

IPC: A61B34/20 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/045 ,  A61B1/05 ,  A61B1/06 ,  A61B1/07 ,  A61B1/313 ,  A61B5/00 ,  A61B17/00 ,  A61B17/02 ,  A61B17/04 ,  A61B17/06 ,  A61B17/062 ,  A61B17/064 ,  A61B17/11 ,  A61B17/115 ,  A61B17/34 ,  A61B34/00 ,  A61B34/30 ,  A61B34/32 ,  A61B90/00 ,  A61B90/13 ,  A61B90/30 ,  A61B90/35 ,  G01S17/36 ,  G02F1/13 ,  G06T1/00 ,  A61B34/10

CPC classification number: G01S17/36 ,  A61B1/00006 ,  A61B1/000094 ,  A61B1/00013 ,  A61B1/00043 ,  A61B1/00045 ,  A61B1/00096 ,  A61B1/00149 ,  A61B1/00194 ,  A61B1/009 ,  A61B1/04 ,  A61B1/045 ,  A61B1/046 ,  A61B1/05 ,  A61B1/051 ,  A61B1/06 ,  A61B1/0605 ,  A61B1/0607 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0661 ,  A61B1/07 ,  A61B1/3132 ,  A61B5/0036 ,  A61B5/0086 ,  A61B5/0095 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/06066 ,  A61B17/062 ,  A61B17/064 ,  A61B17/1114 ,  A61B17/1155 ,  A61B17/3423 ,  A61B34/20 ,  A61B34/30 ,  A61B34/32 ,  A61B34/73 ,  A61B90/03 ,  A61B90/13 ,  A61B90/30 ,  A61B90/35 ,  A61B90/36 ,  A61B90/361 ,  A61B90/37 ,  G02F1/1326 ,  G06T1/0007 ,  A61B1/00009 ,  A61B1/0676 ,  A61B2017/00061 ,  A61B2017/00119 ,  A61B2017/00367 ,  A61B2017/00477 ,  A61B2017/00876 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2057 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B34/25 ,  A61B2034/301 ,  A61B2034/302 ,  A61B2090/061 ,  A61B2090/064 ,  A61B2090/306 ,  A61B2090/367 ,  A61B2090/373 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2505/05 ,  A61B2560/0462 ,  A61B2576/00

Abstract: A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators. In various instances, a robotic camera of the surgical visualization system can monitor and track one or more tagged structures.

公开(公告)号：US20240280696A1

公开(公告)日：2024-08-22

申请号：US18649885

申请日：2024-04-29

Applicant: Exo Imaging, Inc.

Inventor： Yusuf S. HAQUE ,  Sandeep AKKARAJU ,  Janusz BRYZEK ,  Larry SKRENES

IPC: G01S15/89 ,  A61B5/00 ,  A61B8/06 ,  A61B8/14 ,  A61N7/02

CPC classification number: G01S15/8934 ,  G01S15/895 ,  A61B5/0095 ,  A61B8/06 ,  A61B8/145 ,  A61N7/02

Abstract: In one example in accordance with the present disclosure, an imaging device is described. The imaging device includes an array of transducers. Each transducer includes an array of piezoelectric elements. Each piezoelectric element transmits pressure waves towards an object to be imaged and receives reflections of the pressure waves off the object to be imaged. The imaging device also includes a transmit channel per one or more piezoelectric elements to generate the pressure waves and a receive channel per one or more piezoelectric elements to process the reflections of the pressure waves. The number of channels are selectively altered to control parameters such as power consumption and temperature.

公开(公告)号：US12042248B2

公开(公告)日：2024-07-23

申请号：US18215635

申请日：2023-06-28

Applicant: BioVentures, LLC

Inventor： Mark S. Smeltzer ,  Vladimir Zharov ,  Ekaterina Galanzha

IPC: A61B5/00 ,  A61B5/145 ,  A61K41/00 ,  A61K49/22 ,  A61M5/00 ,  G01N33/487 ,  G01N33/569

CPC classification number: A61B5/0095 ,  A61B5/14525 ,  A61B5/4839 ,  A61K41/00 ,  A61K49/221 ,  A61M5/007 ,  G01N33/48728 ,  G01N33/569

Abstract: A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.

公开(公告)号：US20240225455A1

公开(公告)日：2024-07-11

申请号：US18559024

申请日：2022-04-28

Applicant: ECLYPIA

Inventor： Romain BLANC ,  Jean-Guillaume COUTARD ,  Alexandre GALLEGOS ,  Thibault LE ROUX-MALLOUF ,  Freddy RUNGET

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0095 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/6802 ,  A61B5/7246 ,  A61B5/7435

Abstract: A process for non-invasively analyzing a target with an analysis apparatus comprises an intensity modulation device, a light emitter emitting an intensity-modulated light, a detection cell comprising a sensor sensing directly or indirectly a thermal wave propagating out of the target in response to an irradiation of said target by the light emitted, a processor module configured to receive and process sensor data from at least one detection cell. The process comprises carrying out at least two irradiations of the target with the light emitter in a first mode, the modulation frequency of the intensity of the light emitted being swept during each of the irradiations in the first mode over a frequency sweep range, and the processor module receiving sensor data from a detection cell for each of the at least one irradiation in the first mode and forming with the processor module a time series.

公开(公告)号：US12029527B2

公开(公告)日：2024-07-09

申请号：US17449671

申请日：2021-10-01

Applicant: SYNAPTIVE MEDICAL INC.

Inventor： Siu Wai Jacky Mak ,  Michael Frank Gunter Wood ,  Thanh Vinh Vuong

IPC: A61B5/00 ,  A61B5/055 ,  A61B34/20 ,  A61B90/00 ,  G06T7/00 ,  G16H20/40 ,  G16H30/40

CPC classification number: A61B5/0066 ,  A61B5/055 ,  A61B5/7425 ,  A61B34/20 ,  A61B90/37 ,  G06T7/0012 ,  G16H20/40 ,  G16H30/40 ,  A61B5/0095 ,  A61B2034/2065 ,  A61B2090/3735 ,  A61B2090/374 ,  G06T2207/10088 ,  G06T2207/10101

Abstract: A computing device and methods for tracking surgical imaging devices stores a preoperative image of patient tissue registered to a frame of reference of a tracking system; and receives, from a first imaging device, a first intraoperative image of a first region of the tissue, with a finer resolution than the preoperative image. The computing device receives a position of the first imaging device from the tracking system, and registers the first intraoperative image with the frame of reference. The computing device receives, from a second imaging device, a second intraoperative image of a second region of the patient tissue, with a finer resolution than the first intraoperative image. The computing device registers the second intraoperative image to the first intraoperative image; and controls a display to present the preoperative image overlaid with the first intraoperative image, and the first intraoperative image overlaid with the second intraoperative image.

公开(公告)号：US20240210360A1

公开(公告)日：2024-06-27

申请号：US18455948

申请日：2023-08-25

Applicant: Barbara S. Smith ,  Christopher Miranda ,  Ethan B. Marschall

Inventor： Barbara S. Smith ,  Christopher Miranda ,  Ethan B. Marschall

IPC: G01N29/24 ,  A61B5/00 ,  G01N21/17 ,  G01N29/22 ,  G02B21/00

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/221 ,  G02B21/0004 ,  G01N2291/106

Abstract: A photoacoustic and optical microscopy combiner. The combiner is configured to support a transducer defining an axis. The combiner includes a body including a base and an opening extending through the base, and a glass member at least partially positioned within the opening. The glass member includes a surface positioned at an angle relative to the base and the axis of the transducer. A sample slide is supported on the body and at least partially over the opening. The sample slide is positioned such that a sample on the sample slide is configured to receive light from a laser and redirect the light to an ultrasound transducer to generate a real-time image of a sample.

公开(公告)号：US12016650B2

公开(公告)日：2024-06-25

申请号：US17245808

申请日：2021-04-30

Applicant: PHILIPS IMAGE GUIDED THERAPY CORPORATION

Inventor： Richard E. Mansker ,  Michael A. Echeverria

IPC: A61B5/00 ,  A61B6/00 ,  A61B8/00 ,  A61B8/12 ,  G16H10/60 ,  G16H40/40 ,  G16H40/63 ,  A61B5/026 ,  A61B5/029 ,  A61B5/055 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14 ,  A61B90/00

CPC classification number: A61B5/0035 ,  A61B5/0036 ,  A61B6/4417 ,  A61B6/481 ,  A61B8/12 ,  A61B8/4416 ,  G16H10/60 ,  G16H40/40 ,  G16H40/63 ,  A61B5/0066 ,  A61B5/0095 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/055 ,  A61B5/4836 ,  A61B8/54 ,  A61B2018/00791 ,  A61B18/02 ,  A61B18/1492 ,  A61B2090/378 ,  A61B2560/029

Abstract: A dependency-based startup method in a multi-modality medical processing system that includes receiving initialization information about a plurality of executable components to be started, the plurality of executable components including an executable modality component configured to communicate with a medical device communicatively coupled to the multi-modality medical processing system. The method also includes receiving dependency information about the executable modality component, the dependency information identifying one or more of the executable components upon which the executable modality component depends and transforming the initialization information and the dependency information into a dependency map that represents the dependencies between the plurality of executable components. Further, the method includes deriving a start order for the plurality of executable components based on the dependency map and starting the plurality of executable components in the multi-modality medical processing system according to the start order.

公开(公告)号：US11992367B2

公开(公告)日：2024-05-28

申请号：US16941678

申请日：2020-07-29

Applicant: FUJIFILM Corporation

Inventor： Yuzo Nagata ,  Yoshihiro Nakai ,  Shigeki Uehira

IPC: A61B8/00 ,  A61B5/00 ,  C08F212/08 ,  C08F230/08 ,  C08F283/12 ,  C08F290/06 ,  C08G18/61 ,  G10K11/30 ,  H04R17/00

CPC classification number: A61B8/4281 ,  A61B5/0095 ,  A61B8/4444 ,  A61B8/445 ,  C08F212/08 ,  C08F283/12 ,  C08F290/068 ,  C08G18/61 ,  G10K11/30 ,  C08F230/08 ,  H04R17/005 ,  C08F212/08 ,  C08F220/282 ,  C08F230/08 ,  C08F212/08 ,  C08F230/08 ,  C08F220/14 ,  C08F220/14 ,  C08F230/08 ,  C08F230/08 ,  C08F220/24 ,  C08F220/14 ,  C08F230/08 ,  C08F220/24 ,  C08F212/08 ,  C08F230/08 ,  C08F212/20 ,  C08F212/08 ,  C08F230/08 ,  C08F212/20 ,  C08F220/54

Abstract: Provided are a resin material that provides a resin shaped article (such as a resin sheet) having an acoustic impedance close to that of a living body, a reduced acoustic wave attenuation even at high frequencies (such as 10 MHz), and high hardness and high tear strength, and that is suitable as a lens material for acoustic wave probes; an acoustic lens, an acoustic wave probe, an acoustic wave determination device, an ultrasound diagnostic apparatus, a photo-acoustic wave determination device, and an ultrasonic endoscope that employ the above-described resin material as a constituent material; and a method for producing the above-described acoustic lens.

公开(公告)号：US20240122530A1

公开(公告)日：2024-04-18

申请号：US18543277

申请日：2023-12-18

Applicant: The Johns Hopkins University

Inventor： Jeeun KANG ,  Raymond C. KOEHLER ,  Ernest M. GRAHAM ,  Emad M. BOCTOR ,  Jennifer LEE-SUMMERS

IPC: A61B5/00

CPC classification number: A61B5/4362 ,  A61B5/0095 ,  A61B5/4064 ,  A61B5/6823 ,  A61B2503/02 ,  A61B2503/045 ,  A61B2560/0214

Abstract: The present disclosure is associated with monitoring health of a patient. An example photoacoustic monitoring device includes a light-guiding component to guide light energy toward tissue to cause the light energy to be absorbed by the tissue; an ultrasound transmission component to transmit acoustic energy toward the tissue to cause a biological response from the tissue; and a sensing component to perform one or more of ultrasound or photoacoustic imaging to sense the biological response from the tissue and permit a status of the tissue to be determined. In some implementations, the biological response is sensed based on the light energy absorbed by the tissue during the biological response caused by the acoustic energy transmitted toward the tissue.