公开(公告)号：US20240043937A1

公开(公告)日：2024-02-08

申请号：US18268858

申请日：2021-08-26

Applicant: BERTIS INC

Inventor： Sangwon LEE ,  Jingi BAE ,  Dowoon NAM ,  Daehee HWANG ,  Jin-Young JANG ,  Cheolju LEE ,  Sungho SHIN ,  Min-Sik KIM

IPC: C12Q1/6886 ,  C12Q1/6806

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  G01N2800/56 ,  G01N2800/7028

Abstract: The present invention relates to a method of determining the subtype of a pancreatic ductal adenocarcinoma patient through proteogenomic analysis of PDAC. The method of determining the subtype of pancreatic cancer according to one embodiment of the present invention comprises steps of: (1) pulverizing a pancreatic ductal adenocarcinoma lesion tissue isolated from a pancreatic ductal adenocarcinoma patient; (2) obtaining a peptide sample for the patient by extracting and digesting proteins from the lesion tissue; (3) measuring the expression levels of representative genes of pancreatic ductal adenocarcinoma subtypes 1 to 6 from the peptide sample for the patient; and (4) determining the subtype of the pancreatic ductal adenocarcinoma patient by comparing the expression levels of the representative genes of pancreatic ductal adenocarcinoma subtypes 1 to 6.