公开(公告)号：US20210292692A1

公开(公告)日：2021-09-23

申请号：US17262413

申请日：2019-07-19

Applicant: BEX CO., LTD.

Inventor： So MAKABE ,  Hiromichi WATANABE ,  Yasuhiro MORIIZUMI ,  Toshiyuki MORIIZUMI

IPC: C12M1/00 ,  C12N15/87 ,  C12M1/42

Abstract: Provided are a bubble ejection method based on a novel principle, a power supply device used for performing the bubble ejection method, and a bubble ejecting apparatus. A bubble can be ejected by a bubble ejection method for bubble ejection into a conductor, the bubble ejection method includes steps of: contacting a bubble generating electrode to a conductor; contacting a counter electrode to the conductor or a processing target; and applying a negative voltage to the bubble generating electrode, and a conductive material is exposed on at least a tip part of the bubble generating electrode.

公开(公告)号：US20250034560A1

公开(公告)日：2025-01-30

申请号：US18689848

申请日：2022-09-06

Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY ,  BEX CO., LTD.

Inventor： Ikuo NAKAMURA ,  So MAKABE ,  Yuichi KOBASHI ,  Yasuhiro MORIIZUMI

IPC: C12N15/11 ,  C12N9/22

Abstract: An object is to provide a nucleic acid sequence modifying composition and a method for modifying a target site of a nucleic acid sequence that do not depend on a PAM sequence or a PFS sequence. The object can be achieved by a nucleic acid sequence modifying composition including RNA and a fusion protein, in which the RNA includes a hybridization region that may hybridize to a sequence on the 5′ side or the 3′ side of a target site of a nucleic acid sequence, and a guide region that guides the fusion protein, the guide region includes a recognition region that forms a complex with the fusion protein, and the fusion protein includes a binding domain that recognizes the recognition region of the RNA and forms a complex with the recognition region and a modification domain that modifies the target site of the nucleic acid sequence.

公开(公告)号：US20250014777A1

公开(公告)日：2025-01-09

申请号：US18579839

申请日：2022-06-13

Applicant: BEX CO., LTD.

Inventor： Yusuke SAITO ,  So MAKABE ,  Yasuhiro MORIIZUMI

IPC: H01B5/00 ,  C12M1/42

Abstract: An object is to provide an electrode that is easily arranged at a predetermined position when electroporation is performed. The object is achieved by an electrode used for performing electroporation, the electrode includes: at least two or more conductors; and a member configured to hold each conductor and expose at least one end of each of the conductors to outside, the member has a first face where the one end of each of the conductors is exposed, and at least one or more protruding parts provided to the first face, and the length by which the one or more protruding parts protrude in an axis direction from the first face is longer than the length by which the one end of each of the conductors is exposed from the first face.