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公开(公告)号：US20190072561A1
公开(公告)日：2019-03-07
申请号：US16102587
申请日：2018-08-13
发明人： Rui Xing , Youyong Lu , Zhibo Gao , Wenmei Li , Jiantao Cui , Lin Li , Longyun Chen
IPC分类号： G01N33/574 , C12Q1/6886
摘要： The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
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公开(公告)号：US10962545B2
公开(公告)日：2021-03-30
申请号：US16102587
申请日：2018-08-13
发明人： Rui Xing , Youyong Lu , Zhibo Gao , Wenmei Li , Jiantao Cui , Lin Li , Longyun Chen
IPC分类号： C12Q1/6886 , G01N33/574 , C07K16/28
摘要： The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
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公开(公告)号：US10073100B2
公开(公告)日：2018-09-11
申请号：US14869724
申请日：2015-09-29
发明人： Rui Xing , Youyong Lu , Zhibo Gao , Wenmei Li , Jiantao Cui , Lin Li , Longyun Chen
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/6886 , C07K16/28
CPC分类号： G01N33/57492 , C07K16/2833 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , G01N33/57446 , G01N2333/5434 , G01N2333/70539 , G01N2333/70596
摘要： The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
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公开(公告)号：US20160131657A1
公开(公告)日：2016-05-12
申请号：US14869724
申请日：2015-09-29
发明人： Rui Xing , Youyong Lu , Zhibo Gao , Wenmei Li , Jiantao Cui , Lin Li , Longyun Chen
IPC分类号： G01N33/574 , C12N15/113 , C12Q1/68 , C07K16/28
CPC分类号： G01N33/57492 , C07K16/2833 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , G01N33/57446 , G01N2333/5434 , G01N2333/70539 , G01N2333/70596
摘要： The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
摘要翻译： 本发明涉及通过检测HLA I类分子和/或拷贝数的蛋白质表达水平来检测和/或诊断癌细胞的转移潜力或用于评估癌症患者的预后的方法，试剂盒和组合物 编码HLA I类分子的多核苷酸的变异。 本发明还涉及HLA I类分子的蛋白质表达水平和/或编码HLA I类分子的多核苷酸的拷贝数变异作为癌症的预后生物标志物和转移预测生物标志物的用途。
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