公开(公告)号：US20210277162A1

公开(公告)日：2021-09-09

申请号：US17252560

申请日：2019-12-26

申请人： BIOCOMPATIBLES UK LIMITED

发明人： Andrew Lennard LEWIS ,  Hugh BRITTON ,  Yiqing TANG ,  Jonathan VINCE ,  Koorosh ASHRAFI ,  Damien GUEGAN

IPC分类号： C08F261/04 ,  A61K9/16 ,  A61K9/00 ,  C08G67/00 ,  A61L24/00 ,  A61K49/04 ,  A61L24/04

摘要： A hydrophilic polymer comprising pendent groups of the formula I: Wherein: W is independently selected from —OH, —COOH, —SO3H, —OPO3H, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C═O)—O—C1-4alkyl and —O—(C═O)C1-4alkyl; or a group —BZ; wherein —OH, COOH, O—PO3H and SO3H maybe in the form of a pharmaceutically acceptable salt; wherein: B is a bond, or a straight branched alkanediyl, oxyalkylene, alkylene oxaalkylene, or alkylene (oligooxalkylene) group, optionally containing one or more fluorine substituents; and Z is an ammonium, phosphonium, or sulphonium phosphate or phosphonate ester zwitterionic group; X is either a bond or a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; G is a coupling group through which the group of the formula I is coupled to the polymer and is selected from ether, ester, amide, carbonate, carbamate, 1,3 dioxolone, and 1,3 dioxane; R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2 q is an integer from to 4; n is an integer from 1 to 4; p is an integer from 1 to 3; and n+p is from 2 to 5; and wherein —COOH, —OPO3H2 and —SO3H as well as phenolic —OH maybe in the form of a pharmaceutically acceptable salt.