公开(公告)号：US12037398B2

公开(公告)日：2024-07-16

申请号：US15734915

申请日：2019-05-31

Applicant: BIOGEN MA INC.

Inventor： Janine Lisa Ferrant-Orgettas ,  Robert Blake Pepinsky ,  Ellen Duggan Cahir-McFarland ,  Nadia Giselle D'Lima ,  Joseph Walter Arndt ,  Karl John Mortley Hanf ,  Thomas Owen Cameron ,  Ellen Garber Stark

IPC: A61P35/00 ,  C07K16/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to anti-VLA-4 antibodies and binding fragments thereof. The invention further includes polynucleotides encoding said antibodies and binding fragments thereof and methods of manufacturing said antibodies and binding fragments thereof. The invention further includes methods of treating patients suffering from multiple sclerosis and/or epilepsy by administration of said antibodies and binding fragments thereof. The invention further includes methods of reducing the susceptibility to scrambling of a recombinant anti-alpha 4 antibody or a binding fragment thereof.