公开(公告)号：US20220089592A1

公开(公告)日：2022-03-24

申请号：US17421348

申请日：2020-01-17

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Magnus Pfaffenbach ,  Tricia May-dracka ,  Ryan Evans ,  Fang Gao ,  Istvan Enyedy ,  Zhili Xin ,  Philippe Bolduc ,  Emily Anne Peterson

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

Abstract: This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I′), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.