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公开(公告)号:US20220089592A1
公开(公告)日:2022-03-24
申请号:US17421348
申请日:2020-01-17
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Magnus Pfaffenbach , Tricia May-dracka , Ryan Evans , Fang Gao , Istvan Enyedy , Zhili Xin , Philippe Bolduc , Emily Anne Peterson
IPC: C07D471/04 , C07D519/00 , C07D487/04
Abstract: This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I′), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.
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公开(公告)号:US20210340107A1
公开(公告)日:2021-11-04
申请号:US17221358
申请日:2021-04-02
Applicant: BIOGEN MA INC.
Inventor: Brian Stuart Lucas , Edward Yin Shiang Lin , Andrew George Capacci , Zhili Xin , Istvan Enyedy , TeYu Chen , John H. Jones , Kurt D. van Vloten
IPC: C07D217/04 , C07D217/08 , C07D217/20 , C07D217/22 , C07D223/14 , C07D311/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D413/06 , C07D498/04
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US10968181B2
公开(公告)日:2021-04-06
申请号:US16473667
申请日:2017-12-27
Applicant: BIOGEN MA INC.
Inventor: Brian Stuart Lucas , Edward Yin-Shiang Lin , Andrew George Capacci , Zhili Xin , Istvan Enyedy , TeYu Chen , John H. Jones , Kurt D. van Vloten
IPC: C07D311/76 , C07D217/04 , C07D217/08 , C07D223/16 , C07D498/14 , A61K31/352 , A61K31/47 , C07D217/20 , C07D217/22 , C07D223/14 , C07D311/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D413/06 , C07D498/04
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US20190389836A1
公开(公告)日:2019-12-26
申请号:US16481772
申请日:2018-01-29
Applicant: BIOGEN MA INC.
Inventor: Andrew George Capacci , Michael Dechantsreiter , Istvan Enyedy , John H. Jones , Edward Yin-Shiang Lin , Brian Stuart Lucas , Bin Ma
IPC: C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14 , C07D215/14 , C07D405/14 , C07D471/04 , C07D451/02
Abstract: Provided are tetrahydroisoquinoline derivatives as Nrf2 activators.
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