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1.发明授权公开(公告)号：US11918633B2
公开(公告)日：2024-03-05
申请号：US17747697
申请日：2022-05-18
Applicant: BIOMARIN PHARMACEUTICAL INC.
Inventor： Debra Lounsbury
CPC classification number: A61K38/51 , A61P3/00 , C12Y403/01024
Abstract: Phenylalanine ammonia-lyase (PAL) variants with a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL for therapeutic uses, including the treatment of adolescent subjects having PKU.
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