公开(公告)号：US20230192799A1

公开(公告)日：2023-06-22

申请号：US17642150

申请日：2020-09-16

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Daniel J. Wendt ,  Geoffrey Berguig ,  Karol Estrada ,  Jonathan LeBowitz

IPC分类号： C07K14/58 ,  A61K47/54 ,  A61P19/08

CPC分类号： C07K14/58 ,  A61K47/542 ,  A61P19/08 ,  A61K38/00

摘要： The present disclosure, relates, in general, to stable variants of C-type natriuretic peptide (CNP) and uses thereof to treat bone-related disorders.

公开(公告)号：US20220280647A1

公开(公告)日：2022-09-08

申请号：US17634034

申请日：2020-08-12

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Jake Ang ,  Sunil Kumar Battu ,  Joshua Laber ,  Karol Estrada ,  Jonathan LeBowitz ,  Joyce Chou

IPC分类号： A61K47/52 ,  A61K47/54 ,  A61K9/00 ,  A61K9/14 ,  A61P19/00

摘要： The present disclosure, relates, in general, to hydrophobic salts of hydrophilic peptides that form low solubility materials in aqueous solutions and are capable of extended or sustained release of the peptide component when administered to a subject. Hydrophobic salts of C-type natriuretic peptides and uses thereof are also disclosed.