公开(公告)号：US20230192799A1

公开(公告)日：2023-06-22

申请号：US17642150

申请日：2020-09-16

Applicant: BIOMARIN PHARMACEUTICAL INC.

Inventor： Daniel J. Wendt ,  Geoffrey Berguig ,  Karol Estrada ,  Jonathan LeBowitz

IPC: C07K14/58 ,  A61K47/54 ,  A61P19/08

CPC classification number: C07K14/58 ,  A61K47/542 ,  A61P19/08 ,  A61K38/00

Abstract: The present disclosure, relates, in general, to stable variants of C-type natriuretic peptide (CNP) and uses thereof to treat bone-related disorders.

公开(公告)号：US11739345B2

公开(公告)日：2023-08-29

申请号：US16407015

申请日：2019-05-08

Applicant: BIOMARIN PHARMACEUTICAL INC.

Inventor： Geoffrey Berguig ,  Rajeev Mahimkar ,  Hassibullah Akeefe ,  Peter Colosi

IPC: C12N15/864 ,  C12N15/12 ,  C12N15/63 ,  A61K48/00 ,  C12N7/01 ,  C12N7/02 ,  C12N15/86 ,  A61P3/00 ,  C12N7/00 ,  G01N33/94

CPC classification number: C12N15/86 ,  A61K48/0066 ,  A61P3/00 ,  C12N7/00 ,  G01N33/9406 ,  C12N2830/50

Abstract: Provided herein are methods of treating phenylketonuria by normalizing levels of amino acids, neurotransmitters, and neurotransmitter metabolites in a subject having phenylketonuria.