公开(公告)号：US20230322864A1

公开(公告)日：2023-10-12

申请号：US18063589

申请日：2022-12-08

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Peter Cameron COLOSI ,  Michael LOCHRIE ,  Robert NG

IPC分类号： C07K14/005 ,  C12N15/86 ,  A61P21/00

CPC分类号： C07K14/005 ,  C12N15/86 ,  A61P21/00 ,  C12N2750/14122 ,  C12N2750/14143

摘要： The invention relates to novel adeno-associated virus (AAV) capsid proteins, AAV particles comprising a novel capsid protein, polynucleotides encoding these capsid proteins and AAV vectors expressing these capsid proteins. The invention also relates to methods of making the herein described AAV vectors expressing the novel capsid proteins of the invention and associated therapeutic uses of thereof.

公开(公告)号：US20220402974A1

公开(公告)日：2022-12-22

申请号：US16319877

申请日：2017-07-25

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Peter Cameron Colosi ,  Michael LOCHRIE ,  Robert NG

IPC分类号： C07K14/005 ,  C12N15/86

摘要： The invention relates to novel adeno-associated virus (AAV) capsid proteins, AAV particles comprising a novel capsid protein, polynucleotides encoding these capsid proteins and AAV vectors expressing these capsid proteins. The invention also relates to methods of making the herein described AAV vectors expressing the novel capsid proteins of the invention and associated therapeutic uses of thereof.

公开(公告)号：US20240317813A1

公开(公告)日：2024-09-26

申请号：US18676309

申请日：2024-05-28

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Peter Cameron COLOSI ,  Michael LOCHRIE ,  Robert NG

IPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  A61P21/00 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61P21/00 ,  C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152

摘要： The invention relates to novel adeno-associated virus (AAV) capsid proteins, AAV particles comprising a novel capsid protein, polynucleotides encoding these capsid proteins and AAV vectors expressing these capsid proteins. The invention also relates to methods of making the herein described AAV vectors expressing the novel capsid proteins of the invention and associated therapeutic uses of thereof.

公开(公告)号：US20230075854A1

公开(公告)日：2023-03-09

申请号：US17760227

申请日：2021-02-09

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Michael LOCHRIE ,  Peter COLOSI ,  Barrie CARTER ,  Tomas CINEK

IPC分类号： C12N7/00

摘要： The invention is directed to methods of removing adventitious virus from cells and cell lines and virus-free cells and cell lines obtainable by such methods.