公开(公告)号：US10758614B2

公开(公告)日：2020-09-01

申请号：US15317086

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/395 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  C07K16/30 ,  C07K16/28 ,  A61K31/505 ,  A61K31/415 ,  A61K45/06 ,  C07K16/22 ,  A61K47/68 ,  A61K39/00

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a topoisomerase inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

公开(公告)号：US10434174B2

公开(公告)日：2019-10-08

申请号：US15317084

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/395 ,  A61K31/555 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K31/282 ,  A61K33/24 ,  A61K39/00

摘要： Methods, pharmaceutical compositions, and kits for treating a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a platinum agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof.

公开(公告)号：US11033621B2

公开(公告)日：2021-06-15

申请号：US15317074

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/22 ,  A61K47/68 ,  A61K31/192 ,  A61K31/337 ,  A61K31/415 ,  A61K31/4745

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from the group consisting of an anti-angiogenic agent, a vascular disrupting agent (VDA), and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided.

公开(公告)号：US11033620B2

公开(公告)日：2021-06-15

申请号：US15317067

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/22 ,  A61K31/337

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a microtubule inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

公开(公告)号：US10758613B2

公开(公告)日：2020-09-01

申请号：US15317055

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/395 ,  A61K31/513 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  C07K16/18 ,  C07K16/22 ,  A61K31/337 ,  A61K47/68 ,  A61K45/06 ,  C07K16/30 ,  A61K39/00

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from an anti-metabolite agent or analog thereof and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

公开(公告)号：US11034757B2

公开(公告)日：2021-06-15

申请号：US15317069

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/00 ,  C07K16/22 ,  A61K39/395 ,  C07K16/28 ,  A61K31/192 ,  A61K31/4745 ,  C07K16/30

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment of the present invention, and (b) a therapeutically effective amount of a combination therapy including bevacizumab and at least one additional therapeutic agent; or a therapeutically effective amount of at least one additional therapeutic agent selected from the group consisting of a COX-2 inhibitor (COXIB), a non-steroidal anti-inflammatory drug (NSAID), a prostaglandin E2 (PGE2) synthase inhibitor, and combinations thereof. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

公开(公告)号：US09790282B2

公开(公告)日：2017-10-17

申请号：US14779586

申请日：2014-03-24

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  BIOMED VALLEY DISCOVERIES, INC.

发明人： Rimas J Orentas ,  Zhongyu Zhu ,  Crystal L Mackall ,  Dimiter S Dimitrov ,  Bradley St. Croix ,  Saurabh Saha

IPC分类号： C07K16/30 ,  G01N33/574 ,  C07K16/28

CPC分类号： C07K16/30 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/57492

摘要： Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

公开(公告)号：US09765142B2

公开(公告)日：2017-09-19

申请号：US15028337

申请日：2014-10-13

申请人： The United States of America, as represented by the Secretary Department of Health and Human Services ,  BioMed Valley Discoveries, Inc.

发明人： Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire ,  Saurabh Saha ,  Xiaoyan Michelle Zhang ,  Gary Decrescenzo ,  Dean Welsch

IPC分类号： C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  G01N33/574 ,  C07K16/28 ,  A61K47/48 ,  A61K9/00 ,  A61K45/06 ,  A61K49/16 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K9/0019 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K49/16 ,  A61K2039/505 ,  A61K2039/54 ,  C07K14/7051 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57419

摘要： Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.

公开(公告)号：US10799584B2

公开(公告)日：2020-10-13

申请号：US15317063

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K39/395 ,  A61K45/06 ,  A61K31/675 ,  C07K16/28 ,  A61K47/68 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  C07K16/30 ,  A61K39/00

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an alkylating agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

公开(公告)号：US10758526B2

公开(公告)日：2020-09-01

申请号：US15317079

申请日：2015-06-09

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Saurabh Saha ,  Xiaoyan M. Zhang ,  Dimiter Dimitrov ,  Zhongyu Zhu ,  Brad St. Croix ,  Enrique Zudaire

IPC分类号： A61K31/4745 ,  A61K39/395 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00

摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.