-
公开(公告)号：US11034757B2
公开(公告)日：2021-06-15
申请号：US15317069
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/00 , C07K16/22 , A61K39/395 , C07K16/28 , A61K31/192 , A61K31/4745 , C07K16/30
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment of the present invention, and (b) a therapeutically effective amount of a combination therapy including bevacizumab and at least one additional therapeutic agent; or a therapeutically effective amount of at least one additional therapeutic agent selected from the group consisting of a COX-2 inhibitor (COXIB), a non-steroidal anti-inflammatory drug (NSAID), a prostaglandin E2 (PGE2) synthase inhibitor, and combinations thereof. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US09765142B2
公开(公告)日：2017-09-19
申请号：US15028337
申请日：2014-10-13
申请人： The United States of America, as represented by the Secretary Department of Health and Human Services , BioMed Valley Discoveries, Inc.
发明人： Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire , Saurabh Saha , Xiaoyan Michelle Zhang , Gary Decrescenzo , Dean Welsch
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395 , G01N33/574 , C07K16/28 , A61K47/48 , A61K9/00 , A61K45/06 , A61K49/16 , C07K14/725 , C07K14/705 , A61K39/00
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6865 , A61K49/16 , A61K2039/505 , A61K2039/54 , C07K14/7051 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N33/57419
摘要： Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
-
公开(公告)号：US11033621B2
公开(公告)日：2021-06-15
申请号：US15317074
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , C07K16/22 , A61K47/68 , A61K31/192 , A61K31/337 , A61K31/415 , A61K31/4745
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from the group consisting of an anti-angiogenic agent, a vascular disrupting agent (VDA), and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided.
-
公开(公告)号：US11033620B2
公开(公告)日：2021-06-15
申请号：US15317067
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , C07K16/28 , C07K16/22 , A61K31/337
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a microtubule inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US10758613B2
公开(公告)日：2020-09-01
申请号：US15317055
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/395 , A61K31/513 , A61K31/4745 , A61K31/7068 , A61K33/24 , C07K16/18 , C07K16/22 , A61K31/337 , A61K47/68 , A61K45/06 , C07K16/30 , A61K39/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from an anti-metabolite agent or analog thereof and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US10758614B2
公开(公告)日：2020-09-01
申请号：US15317086
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/395 , A61K31/337 , A61K31/4745 , A61K31/704 , C07K16/30 , C07K16/28 , A61K31/505 , A61K31/415 , A61K45/06 , C07K16/22 , A61K47/68 , A61K39/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a topoisomerase inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US10434174B2
公开(公告)日：2019-10-08
申请号：US15317084
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/395 , A61K31/555 , C07K16/22 , C07K16/28 , C07K16/30 , A61K31/282 , A61K33/24 , A61K39/00
摘要： Methods, pharmaceutical compositions, and kits for treating a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a platinum agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof.
-
公开(公告)号：US10799584B2
公开(公告)日：2020-10-13
申请号：US15317063
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K39/395 , A61K45/06 , A61K31/675 , C07K16/28 , A61K47/68 , A61K31/4745 , A61K31/7068 , A61K33/24 , C07K16/30 , A61K39/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an alkylating agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US10758526B2
公开(公告)日：2020-09-01
申请号：US15317079
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K31/4745 , A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
-
公开(公告)号：US10196443B2
公开(公告)日：2019-02-05
申请号：US15680177
申请日：2017-08-17
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BIOMED VALLEY DISCOVERIES, INC.
发明人： Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire , Saurabh Saha , Xiaoyan Michelle Zhang , Gary Decrescenzo , Dean Welsch
IPC分类号： C07H21/04 , C12N15/09 , C12N15/63 , A61P35/00 , G01N33/574 , A61P31/04 , C07K16/30 , A61K39/395 , C07K16/28 , A61K47/68 , A61K9/00 , A61K45/06 , A61K49/16 , C07K14/725 , C07K14/705 , A61K39/00
摘要： Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.033 秒)
