公开(公告)号：US10738027B2

公开(公告)日：2020-08-11

申请号：US16227820

申请日：2018-12-20

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X. M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K45/06 ,  A61P35/00 ,  A61K31/4439

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US10183927B2

公开(公告)日：2019-01-22

申请号：US15598181

申请日：2017-05-17

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X. M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K45/06 ,  A61P35/00 ,  A61K31/4439

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US09676746B2

公开(公告)日：2017-06-13

申请号：US15011377

申请日：2016-01-29

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X. M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K45/06 ,  A61K31/4439

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20200339531A1

公开(公告)日：2020-10-29

申请号：US16922365

申请日：2020-07-07

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X.M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20160221987A1

公开(公告)日：2016-08-04

申请号：US15011377

申请日：2016-01-29

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X.M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K45/06 ,  A61K31/4439

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

摘要翻译： 本发明提供式（I）化合物的结晶形式：还提供药物组合物，其包括提供的结晶形式和使用所提供的结晶形式和用于治疗癌症的药物组合物的方法。

公开(公告)号：US20220324832A1

公开(公告)日：2022-10-13

申请号：US17842632

申请日：2022-06-16

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X.M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20190127348A1

公开(公告)日：2019-05-02

申请号：US16227820

申请日：2018-12-20

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X.M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K31/4439 ,  A61P35/00 ,  A61K45/06

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20170320851A1

公开(公告)日：2017-11-09

申请号：US15598181

申请日：2017-05-17

申请人： BIOMED VALLEY DISCOVERIES, INC. ,  VERTEX PHARMACEUTICALS INCORPORATED

发明人： Gary DeCrescenzo ,  Dean Welsch ,  Petinka I. Vlahova ,  Stephan X.M. Boerrigter ,  Alexander Aronov ,  Ali Keshavarz-Shokri ,  Alexander N. Scangas ,  Kathy Stavropoulos ,  Benjamin Littler ,  Irina Nikolaevna Kadiyala ,  Rossitza Gueorguieva Alargova

IPC分类号： C07D401/04 ,  A61K45/06 ,  A61K31/4439

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US10076513B2

公开(公告)日：2018-09-18

申请号：US15001036

申请日：2016-01-19

申请人： Vertex Pharmaceuticals Incorporated

发明人： Marinus Jacobus Verwijs ,  Rossitza Gueorguieva Alargova ,  Ritu Rohit Kaushik ,  Irina Nikolaevna Kadiyala ,  Christopher Young

IPC分类号： A61K31/443 ,  C07D405/12 ,  A61K9/20 ,  A61K9/00 ,  A61K9/16 ,  A61K31/47

摘要： A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.

公开(公告)号：US20150164881A1

公开(公告)日：2015-06-18

申请号：US14629097

申请日：2015-02-23

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Hayley Marie Binch ,  Martyn Curtis Botfield ,  Lev Tyler Dewey Fanning ,  Peter Diederik Jan Grootenhuis ,  Dennis James Hurley ,  Irina Nikolaevna Kadiyala ,  Ritu Rohit Kaushik ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Brian Luisi ,  Ales Medek ,  Mehdi Numa ,  Urvi Jagdishbhai Sheth ,  Alina Silina ,  Marinus Jacobus Verwijs ,  Xiaoqing Yang ,  Christopher Ryan Young ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/4709 ,  A61K31/404 ,  C12Q1/34 ,  A61K31/443

CPC分类号： A61K31/4709 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4704 ,  A61K45/06 ,  C07D405/12 ,  C12Q1/34 ,  G01N2500/04 ,  G01N2500/20 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

摘要翻译： 本发明涉及药物组合物，其包含与式II化合物和/或式III化合物中的一种或两种结合的式I化合物。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。