公开(公告)号：US20250066787A1

公开(公告)日：2025-02-27

申请号：US18281251

申请日：2022-03-08

Applicant: BIONEER CORPORATION ,  SIRNAGEN THERAPEUTICS CORPORATION

Inventor： Han-Oh PARK ,  Sang-Kyu LEE ,  Sung-ll YUN ,  Oh Seung KWON ,  Eun-Ah GOH ,  Young-Ho GOH ,  Jun-Hong PARK ,  Kang SONG ,  Jangseon KIM ,  Mi-Sun LEE ,  Soon-Ja CHOI

IPC: C12N15/113 ,  A61K9/00 ,  A61P31/14

Abstract: The present invention relates to a composition for administering a double-stranded oligonucleotide structure using an ultrasonic nebulizer. According to the method, the double-stranded oligonucleotide according to the present invention forms self-assembled nanoparticles, which are 90 nm in size and have a neutral charge, and it is possible to deliver the double-stranded oligonucleotide specifically to the nasal cavity and lungs while maintaining not only the same concentration, molecular weight, purity, nanoparticle size, and osmolality as those of the stock material but also the target gene inhibitory activity without cytotoxicity. Thus, the present invention may be useful for the prevention or treatment of respiratory viral infections including COVID-19, pulmonary fibrosis caused by viral infection, or respiratory diseases.