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    DOUBLE-STRANDED OLIGONUCLEOTIDE TARGETING DKK1 GENE, CONSTRUCT INCLUDING SAME, AND HAIR LOSS PREVENTION OR HAIR GROWTH COMPOSITION CONTAINING SAME
    2.
    发明申请
    DOUBLE-STRANDED OLIGONUCLEOTIDE TARGETING DKK1 GENE, CONSTRUCT INCLUDING SAME, AND HAIR LOSS PREVENTION OR HAIR GROWTH COMPOSITION CONTAINING SAME 有权

    公开(公告)号：US20220088051A1

    公开(公告)日：2022-03-24

    申请号：US17423372

    申请日：2020-01-15

    申请人： BIONEER CORPORATION

    发明人： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Pyoung Oh YOON ,  Sang-Kyu LEE ,  Tae-Rim KIM ,  Young-Ho KO ,  Seung-Seob SON ,  Eun-Ah GOH ,  Hyung-Jin KIM

    IPC分类号： A61K31/713 ,  A61P17/14

    摘要： The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

    TARGET MATERIAL EXTRACTION APPARATUS WITH REPLACEMENT OF MAGNETIC BAR BLOCK ALLOWED
    4.
    发明申请
    TARGET MATERIAL EXTRACTION APPARATUS WITH REPLACEMENT OF MAGNETIC BAR BLOCK ALLOWED 有权

    公开(公告)号：US20210230579A1

    公开(公告)日：2021-07-29

    申请号：US17262796

    申请日：2019-07-23

    申请人： BIONEER CORPORATION

    发明人： Han-Oh PARK ,  Min Sung KOOK

    IPC分类号： C12N15/10

    摘要： The present invention relates to an extraction apparatus capable of simultaneously extracting target materials from multiple biological samples and, more particularly, to a target material extraction apparatus in which magnetic bar blocks can be replaced according to kinds of multi-well plates to be inserted into a cartridge. When used, the target material extraction apparatus of the present invention is operated in such a manner that among various multi-well plates having different numbers of wells, multi-well plates suitable for a use purpose are loaded into a cartridge within the apparatus and magnetic bar blocks equipped with magnetic bars suitable therefor are selected and loaded. Thus, the apparatus has the advantage of selectively applying various multi-well plates to one installment according to the number of samples from which a target material is extracted or to the amount of the target material to be extracted.

    Lactic acid bacteria isolated from mother's milk with probiotic activity and inhibitory activity against body weight augmentation
    5.
    再颁专利
    Lactic acid bacteria isolated from mother's milk with probiotic activity and inhibitory activity against body weight augmentation 有权

    公开(公告)号：USRE48652E1

    公开(公告)日：2021-07-20

    申请号：US15978986

    申请日：2018-05-14

    申请人： BIONEER CORPORATION

    发明人： Ji Hee Kang ,  Byeung Il You ,  Sung Il Yun ,  Han Oh Park

    IPC分类号： C12R1/225 ,  A23L33/18 ,  A23L33/135 ,  A23C9/123 ,  C07K14/335 ,  C12N1/20 ,  A61K38/00

    摘要： The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body. Therefore, the strain of the invention, owing to such beneficiary effects, can be effectively used not only for the production of fermented milk, other fermented food products and animal feeds but also for the production of live cell products and food additives for preventing weight gaining.

    HIGH-SPEED POLYMERASE CHAIN REACTION ANALYSIS PLATE
    6.
    发明申请
    HIGH-SPEED POLYMERASE CHAIN REACTION ANALYSIS PLATE 有权

    公开(公告)号：US20210053059A1

    公开(公告)日：2021-02-25

    申请号：US17040389

    申请日：2019-03-22

    申请人： BIONEER CORPORATION

    发明人： Han Oh PARK ,  Jong Kab KIM ,  Yang Won LEE ,  Sang Ryoung PARK

    IPC分类号： B01L3/00

    摘要： The present invention relates to the structure of an analysis plate applied to a high-speed polymerase chain reaction (PCR), and to a PCR analysis plate used for implementing an analysis of a real-time PCR, a real-time nested PCR and a post-PCR lateral flow hybridization reaction. The present invention is provided with: a check valve for enabling the maintaining of positive pressure when an elastic film expands into a convex form by having a solution pushed therein by the positive pressure; a lateral flow analysis module for analyzing a post-PCR follow-up PCR or lateral flow; and a shut-off valve enabling the controlling of the movement of the solution after each reaction ends. A high-speed PCR analysis plate may be provided whereby, by pressing, by means of a temperature-controllable heating block, the elastic film, which is in a convex form by the solution, of a PCR unit, a PCR solution may undergo rapid temperature circulation with minimum heat resistance, and a PCR dried material and a nucleic acid solution may be homogenized and mixed.

    MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY METHOD
    9.
    发明申请
    MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20190279853A1

    公开(公告)日：2019-09-12

    申请号：US16347040

    申请日：2017-10-30

    申请人： BIONEER CORPORATION

    发明人： Taeman KIM ,  Do Hoon KIM ,  Jong Rok AHN ,  Han-Oh PARK

    IPC分类号： H01J49/04 ,  G01N27/62 ,  H01J49/40

    摘要： The present invention relates to a matrix-assisted laser desorption ionization mass spectrometry method and, specifically, a mass spectrometry method according to the present invention comprises the steps of: acquiring a mass spectrum of an analyte by performing matrix-assisted laser desorption ionization of the analyte, wherein a detection spectrum, which is the mass spectrum of the analyte, is acquired using each of two or more matrixes different from one another; and removing, from each detection spectrum, a peak of a corresponding matrix to obtain a matrix-removed spectrum, and then acquiring a corrected mass spectrum of the analyte on the basis of a matrix-removed spectrum for each of different matrixes.