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公开(公告)号：US20230348912A1
公开(公告)日：2023-11-02
申请号：US17998662
申请日：2021-05-13
发明人： Jun Hong PARK , Han-Oh PARK , Sung Il YUN , Tae Rim KIM , Soo Hyun HWANG , Kang SONG , Sang Hyuk JUNG , Jangseon KIM , Mi Sun LEE , Soonja CHOI , Seung Seob SON
IPC分类号： C12N15/113 , A61K48/00 , A61K47/60 , A61K47/69 , A61P3/04
CPC分类号： C12N15/1136 , A61K48/0025 , A61K47/60 , A61K47/6929 , A61P3/04
摘要： The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.
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公开(公告)号：US20230123164A1
公开(公告)日：2023-04-20
申请号：US17907432
申请日：2021-04-12
申请人： BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION , SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人： Seung Seob SON , Tae Rim KIM , Eun Young LEE , Nam-Jun CHO , Sung Il YUN , Jun Hong PARK , Han-Oh PARK
摘要： The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic kidney disease can advantageously predict the plausibility of progression into end-stage renal disease in advance.
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