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公开(公告)号：US11591471B2
公开(公告)日：2023-02-28
申请号：US17751440
申请日：2022-05-23
发明人： Ingvar Helgason , Dusko Ilic
摘要： Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
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2.发明授权公开(公告)号：US11566133B2
公开(公告)日：2023-01-31
申请号：US16310780
申请日：2017-06-19
摘要： The present invention refers to a composition comprising a solution which in turn comprises an amino acidic chain gelatin polymer derived from natural sources of cold-adapted marine species, at a concentration from 1% to 20% (w/v), which optionally further comprises a polymerizing initiator such as a photoinitiator, and is chemically functionalized to become reactive to polymerization or crosslinking in presence of free radicals. This composition is especially useful for 3D printing, extrusion systems (additive fabrication), spray systems, casting, micro- and nano fibers fabrication systems (electrospinning, solution blow spinning) or microfluidics.
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公开(公告)号：US20220403172A1
公开(公告)日：2022-12-22
申请号：US17751440
申请日：2022-05-23
发明人： Ingvar HELGASON , Dusko ILIC
摘要： Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
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公开(公告)号：US20220378975A1
公开(公告)日：2022-12-01
申请号：US17772399
申请日：2020-11-18
摘要： The invention provides injectable, tough hydrogels that can be crosslinked in situ on demand using minimally-invasive methods, such as visible light exposure is an unmet medical challenge. Among the emerging biopolymers for tissue sealing, gelatin methacryloyl (GelMA), a naturally-derived biopolymer obtained from denatured collagen, has secured a promising role as a result of its excellent bioadhesion, biodegradation, and biocompatibility. To overcome one of the main shortcomings of GelMA, i.e., brittleness, we hybridized it using methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid GelMA-AlgMA hydrogels provide a photocrosslinkable, injectable, and adhesive platform with an excellent toughness that can be engineered using divalent cations, such as calcium. This class of novel hybrid biopolymers with more than 600% improved toughness may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants in minimally invasive procedure, especially for stretchable tissues.
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公开(公告)号：US20220213318A1
公开(公告)日：2022-07-07
申请号：US17498181
申请日：2021-10-11
申请人： Na XU , Yanmei XING , Xuechuan WANG
发明人： Na XU , Yanmei XING , Xuechuan WANG
IPC分类号： C08L77/00 , C08J3/24 , C08L89/06 , D06M15/15 , D06M13/127 , D06M13/507 , D06M10/00
摘要： A method of preparing a vinyl collagen microsphere polyamide fiber composite material includes the following steps: step 1: modifying a collagen with methacrylic anhydride to obtain a vinyl collagen, then emulsifying and cross-linking the vinyl collagen to obtain vinyl collagen microspheres; step 2: treating a polyamide fiber substrate with formaldehyde to obtain a hydroxylated polyamide fiber substrate, treating the hydroxylated polyamide fiber with (3-mercaptopropyl)trimethoxysilane (MPS) to obtain a sulfhydrylated polyamide fiber substrate; and step 3: modifying the sulfhydrylated polyamide fiber substrate with the vinyl collagen microspheres to obtain the vinyl collagen microsphere polyamide fiber composite material.
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公开(公告)号：US11377559B2
公开(公告)日：2022-07-05
申请号：US17366550
申请日：2021-07-02
发明人： Ingvar Helgason , Dusko Ilic
摘要： Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
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公开(公告)号：US20220204707A1
公开(公告)日：2022-06-30
申请号：US17603307
申请日：2020-03-18
申请人： NABORE GmbH
发明人： Ewald WILKA
摘要： The present invention relates to a thermoplastic composite material comprising an organic fibrous material and a thermoplastic binding agent, wherein the thermoplastic binding agent is selected from a polymer from the group comprising styrene-acrylate. Furthermore, the invention relates to a method for producing a thermoplastic composite material and to the use of the thermoplastic composite material.
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公开(公告)号：US20220184274A1
公开(公告)日：2022-06-16
申请号：US17491570
申请日：2020-04-03
申请人： Tessenderlo Group NV
发明人： Fernanda CONDI DE GODOI , Stephan R. DIERCKX , Erwin Theo Maria QUANTEN , Jan Maurits August VANDENDRIESSCHE
摘要： The present invention relates to a gelatin having improved properties, in particular improved dispensing properties, more particularly improved printing properties. The present invention further relates to a construct produced with the gelatin of the present invention and to a process to produce said construct. Further the present invention relates to the use of the gelatin of the present invention to solve existing problems encountered with dispensing systems, in particular with 3D printing and more particularly for applications in the medical field. The gelatin of the present invention is particularly suitable for bio-printing in the medical field and may also be used in cosmetic and in food applications.
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公开(公告)号：US11191869B2
公开(公告)日：2021-12-07
申请号：US16524435
申请日：2019-07-29
申请人： DSM IP Assets B.V.
IPC分类号： A61B17/68 , A61F2/28 , A61B17/70 , C08L89/06 , A61L27/16 , A61B17/72 , A61L26/00 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/58 , C08H1/06 , C08L5/04 , C08L5/08 , C08L67/04 , A61L27/24 , A61L27/56 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/36 , A61L27/38 , A61F2/00 , A61F2/24 , A61F2/30 , A61F2/44 , A61L27/12 , A61L27/26 , A61L27/54 , C08K3/013 , A61B17/00 , A61F2/42
摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
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公开(公告)号：US20210361820A1
公开(公告)日：2021-11-25
申请号：US16965721
申请日：2018-12-20
发明人： Katherine A. BOURDILLON , Craig DELURY , Sophie REGAN , James Sebastian MELLOR , Matthew WESTMORELAND
摘要： An antimicrobial composition may comprise a surfactant. The antimicrobial composition may include about 30 μg/ml to about 1,000 μg/ml of the surfactant, by volume of the antimicrobial composition. The surfactant may comprise a docusate salt such as docusate sodium. The antimicrobial composition may comprise an antimicrobial agent. The antimicrobial composition may include from about 0.01% to about 10% of the antimicrobial agent, by weight of the antimicrobial composition. The antimicrobial agent may comprise polyhexanide (PHMB). In some embodiments, the antimicrobial composition may comprise a matrix-forming material. The antimicrobial composition may include at least 90% of the matrix-forming material, by weight of the antimicrobial composition. The matrix-forming material may comprise collagen, oxidized regenerated cellulose, alginate, carboxymethylcellulose, or combinations thereof.
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