公开(公告)号：US20250025601A1

公开(公告)日：2025-01-23

申请号：US18709430

申请日：2022-11-11

Applicant: SCRIPPS HEALTH

Inventor： Darryl D. D'LIMA ,  Erik W. DORTHE ,  Austin B. WILLIAMS ,  Shawn P. GROGAN

IPC: A61L27/26 ,  A61L27/38 ,  C08L5/10 ,  C08L89/06

Abstract: Disclosed herein are methods of producing a scaffold by producing a biopolymer scaffold composition by pneumatospinning a polymer solution comprising polymer fibers onto a collector; feeding the polymer fiber solution comprising the polymer fiber into an air brush; applying a gas pressure around the polymer fiber solution comprising the polymer fiber in the airbrush; ejecting the polymer fiber from the air brush onto the collector; crosslinking the polymer fibers; and seeding a plurality of cells to the polymer scaffold composition.

公开(公告)号：US12186397B2

公开(公告)日：2025-01-07

申请号：US16173769

申请日：2018-10-29

Applicant: National Cheng Kung University

Inventor： Lynn L. H. Huang

IPC: A61K47/34 ,  A61K38/18 ,  A61K38/19 ,  A61K38/30 ,  A61L24/00 ,  A61L24/08 ,  A61L24/10 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  C08B11/02 ,  C08B11/12 ,  C08B15/00 ,  C08B15/10 ,  C08B37/00 ,  C08B37/08 ,  C08G12/46 ,  C08H1/00 ,  C08H1/06 ,  C08L5/08 ,  C08L89/06 ,  C09J105/08 ,  C12N5/00 ,  C08G69/10 ,  C08L77/04

Abstract: A cell tissue gel, comprising one or more matrix molecules cross-linked with a cross-linking agent, and a quenching agent bound to a reactive group of the cross-linking agent, wherein the quenching agent contains a moiety that is capable of reacting with the reactive group of the cross-linking agent and the one or more matrix molecules contain one or more functional groups that are capable of cross-linking with the reactive group, the amount of the reactive group of the cross-linking agent being equal to or less than a total amount including the amount of the one or more functional groups and the amount of the moiety.

公开(公告)号：US12123117B2

公开(公告)日：2024-10-22

申请号：US16610957

申请日：2017-11-13

Applicant: ROCKWOOL INTERNATIONAL A/S

Inventor： Thomas Hjelmgaard

IPC: D04H1/4218 ,  A01G24/20 ,  A01G24/22 ,  A01N43/60 ,  B29C53/56 ,  B29C70/06 ,  B29K105/12 ,  C03C25/26 ,  C08L1/02 ,  C08L1/08 ,  C08L3/02 ,  C08L3/12 ,  C08L89/06 ,  C08L91/00 ,  D04H1/413 ,  D04H1/4209 ,  D04H1/587 ,  D04H1/64 ,  D04H3/002 ,  D04H3/004 ,  B29K309/00 ,  B29L23/00

CPC classification number: D04H1/4218 ,  A01G24/20 ,  A01G24/22 ,  A01N43/60 ,  B29C53/562 ,  B29C70/06 ,  C03C25/26 ,  C08L1/02 ,  C08L1/08 ,  C08L3/02 ,  C08L3/12 ,  C08L89/06 ,  C08L91/00 ,  D04H1/413 ,  D04H1/4209 ,  D04H1/587 ,  D04H1/64 ,  D04H3/002 ,  D04H3/004 ,  B29K2089/00 ,  B29K2105/12 ,  B29K2309/00 ,  B29L2023/00 ,  C03C2218/11

Abstract: The present invention relates to an aqueous binder composition for mineral fibers comprising—at least one hydrocolloid, —at least one fatty acid ester of glycerol.

公开(公告)号：US12070929B2

公开(公告)日：2024-08-27

申请号：US16099317

申请日：2017-05-11

Applicant: ROCKWOOL INTERNATIONAL A/S

Inventor： Thomas Hjelmgaard

IPC: B32B37/12 ,  B32B5/12 ,  B32B5/26 ,  B32B7/12 ,  B32B15/14 ,  B32B19/04 ,  B32B37/14 ,  B32B37/18 ,  B32B38/00 ,  C03C13/06 ,  C03C25/26 ,  C03C25/32 ,  C03C25/321 ,  C03C25/328 ,  C08J5/04 ,  C08L1/28 ,  C08L3/02 ,  C08L5/12 ,  C08L89/06 ,  C09J5/00 ,  C09J11/06 ,  C09J101/28 ,  C09J103/02 ,  C09J105/00 ,  C09J105/04 ,  C09J105/06 ,  C09J105/12 ,  C09J189/00 ,  C09J189/06 ,  D04H1/413 ,  D04H1/4209 ,  D04H1/4218 ,  D04H1/4266 ,  D04H1/587 ,  D04H1/593 ,  D04H1/64 ,  D04H1/724 ,  D04H1/74 ,  D04H3/002 ,  D04H3/004 ,  E04B1/74 ,  E04B1/80 ,  E04B1/88 ,  E04B1/94 ,  E04C2/284 ,  E04D3/35 ,  E04F13/08 ,  C12N9/02 ,  C12N9/06 ,  C12N9/08 ,  C12N9/10 ,  C12N9/90 ,  E04B1/76

CPC classification number: B32B37/12 ,  B32B5/12 ,  B32B5/26 ,  B32B7/12 ,  B32B15/14 ,  B32B19/04 ,  B32B19/041 ,  B32B37/1207 ,  B32B37/146 ,  B32B37/18 ,  B32B38/0004 ,  C03C13/06 ,  C03C25/26 ,  C03C25/32 ,  C03C25/321 ,  C03C25/328 ,  C08J5/043 ,  C08L1/286 ,  C08L3/02 ,  C08L5/12 ,  C08L89/06 ,  C09H11/00 ,  C09J5/00 ,  C09J11/06 ,  C09J101/28 ,  C09J101/286 ,  C09J103/02 ,  C09J105/00 ,  C09J105/04 ,  C09J105/06 ,  C09J105/12 ,  C09J189/005 ,  C09J189/06 ,  D04H1/413 ,  D04H1/4209 ,  D04H1/4218 ,  D04H1/4266 ,  D04H1/587 ,  D04H1/593 ,  D04H1/64 ,  D04H1/724 ,  D04H1/74 ,  D04H3/002 ,  D04H3/004 ,  E04B1/74 ,  E04B1/80 ,  E04B1/88 ,  E04B1/94 ,  E04C2/284 ,  E04D3/352 ,  E04F13/0866 ,  B32B2037/1215 ,  B32B2037/1253 ,  B32B2037/1269 ,  B32B38/164 ,  B32B2250/20 ,  B32B2250/40 ,  B32B2255/02 ,  B32B2255/26 ,  B32B2262/108 ,  B32B2305/20 ,  B32B2305/72 ,  B32B2307/304 ,  B32B2307/732 ,  B32B2309/02 ,  B32B2315/14 ,  B32B2317/00 ,  B32B2419/06 ,  B32B2607/00 ,  C03C2213/00 ,  C03C2218/11 ,  C08J2301/28 ,  C08J2303/02 ,  C08J2389/06 ,  C08J2405/00 ,  C08J2405/04 ,  C08J2405/06 ,  C08J2405/12 ,  C08J2491/00 ,  C08J2493/00 ,  C08L2201/52 ,  C08L2205/03 ,  C09J2400/146 ,  C09J2401/00 ,  C09J2403/00 ,  C09J2405/00 ,  C09J2489/00 ,  C12N9/0022 ,  C12N9/0051 ,  C12N9/0059 ,  C12N9/0065 ,  C12N9/0071 ,  C12N9/1044 ,  C12N9/90 ,  C12Y104/03013 ,  C12Y108/03002 ,  C12Y110/03001 ,  C12Y111/01007 ,  C12Y114/18001 ,  C12Y203/01013 ,  C12Y203/02013 ,  C12Y503/04001 ,  D10B2505/20 ,  E04B2001/742 ,  E04B2001/743 ,  E04B2001/745 ,  E04B2001/7683 ,  C09J189/06 ,  C08L5/12

Abstract: The invention relates to a method of bonding together surfaces of two or more elements, whereby at least one of the two or more elements is a mineral wool element, said mineral wool element(s) being bound by a mineral wool binder, the method comprising the steps of providing two or more elements; applying an adhesive to one or more of the surfaces to be bonded together before, during or after contacting the surfaces to be bonded together with each other; curing the adhesive, wherein the adhesive comprises at least one protein; at least one phenol and/or quinone containing compound, and/or at least one enzyme.

公开(公告)号：US20240216572A1

公开(公告)日：2024-07-04

申请号：US17781158

申请日：2020-11-27

Applicant: NOVADIP BIOSCIENCES

Inventor： DENIS DUFRANE ,  Nicolas THEYS

IPC: A61L27/12 ,  A61L27/10 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  C08L5/04 ,  C08L5/08 ,  C08L5/12 ,  C08L29/04 ,  C08L31/06 ,  C08L39/06 ,  C08L67/04 ,  C08L89/06

CPC classification number: A61L27/12 ,  A61L27/10 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/38 ,  C08L5/04 ,  C08L5/08 ,  C08L5/12 ,  C08L29/04 ,  C08L31/06 ,  C08L39/06 ,  C08L67/04 ,  C08L89/06 ,  A61L2300/414 ,  A61L2430/34

Abstract: The present invention relates to sterile and desiccated biomaterials comprising devitalized differentiated cells having tissue regenerating and/or repairing properties, and a particulate material, the cells and the particulate material being embedded in an extracellular matrix. The particulate material is preferably gelatin, a ceramic material, or a demineralized bone matrix (DBM).

公开(公告)号：US20240157635A1

公开(公告)日：2024-05-16

申请号：US18381407

申请日：2023-10-18

Applicant: Singapore University of Technology and Design

Inventor： Javier GOMEZ FERNANDEZ ,  Stylianos DRITSAS

IPC: B29C64/20 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y70/10 ,  C08L5/08 ,  C08L89/06

CPC classification number: B29C64/20 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y70/10 ,  C08L5/08 ,  C08L89/06

Abstract: The present invention discloses a system for large scale additive manufacturing, an apparatus for large scale additive manufacturing, and a bio-composite material used for the large scale additive manufacturing. The apparatus and the bio-composite material enable the system to operate in a desired manner. The system is able to facilitate “on demand” manufacturing, is able to provide regional/localised modifications for consumers, is able to minimise transportation/storage costs and also minimises damage to the environment.

公开(公告)号：US20240119865A1

公开(公告)日：2024-04-11

申请号：US18482320

申请日：2023-10-06

Applicant: Life Model Designs LLC

Inventor： Sean P. Gerke

IPC: G09B23/30 ,  C08K3/02 ,  C08K3/30 ,  C08L89/06

CPC classification number: G09B23/30 ,  C08K3/02 ,  C08K3/30 ,  C08L89/06 ,  C08K2003/3045 ,  C08L2205/035

Abstract: A synthetic blood clot and its corresponding method of formulation are described that provide a thrombus simulant capable of being used in synthetic biological pathways, such as for surgery training and/or simulation testing purposes. In one example embodiment, non-biohazardous ingredients such as one or more hydrogels, other thickening agents, coloring agents, and water are combined to form the thrombus simulant. A radiolucent agent may be provided to permit visualization of the thrombus simulant under certain imaging techniques, such as x-rays.

公开(公告)号：US11944722B2

公开(公告)日：2024-04-02

申请号：US17474985

申请日：2021-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L24/04 ,  A61L24/00 ,  A61L27/20 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/00 ,  C08G65/00 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06

CPC classification number: A61L27/44 ,  A61L27/20 ,  A61L27/26 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/0084 ,  C08G65/002 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2400/16 ,  A61L2430/40 ,  C08L2205/04 ,  C08L2312/00 ,  C08L5/04 ,  C08L89/06 ,  C08L89/06 ,  C08L5/04 ,  A61L27/26 ,  C08L89/06 ,  A61L27/26 ,  C08L5/08

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US20230415467A1

公开(公告)日：2023-12-28

申请号：US18367130

申请日：2023-09-12

Applicant: ROCKWOOL A/S

Inventor： Thomas HJELMGAARD

IPC: B32B37/12 ,  C09J101/28 ,  C09J103/02 ,  C09J105/04 ,  C09J105/06 ,  C09J189/06 ,  D04H1/4218 ,  D04H1/74 ,  C09J105/12 ,  B32B5/12 ,  B32B5/26 ,  C08L5/12 ,  C03C25/26 ,  B32B19/04 ,  B32B15/14 ,  C09J105/00 ,  B32B37/14 ,  D04H1/413 ,  D04H1/64 ,  D04H3/002 ,  E04B1/94 ,  C03C13/06 ,  C08L1/28 ,  C08L3/02 ,  D04H3/004 ,  E04B1/88 ,  C09J189/00 ,  C08J5/04 ,  C03C25/32 ,  C09J11/06 ,  D04H1/587 ,  E04B1/74 ,  C08L89/06 ,  D04H1/4266 ,  D04H1/724 ,  B32B7/12 ,  B32B37/18 ,  B32B38/00 ,  C03C25/321 ,  C03C25/328 ,  C09J5/00 ,  D04H1/4209 ,  D04H1/593 ,  E04B1/80 ,  E04C2/284 ,  E04D3/35 ,  E04F13/08

CPC classification number: B32B37/12 ,  C09J101/286 ,  C09J103/02 ,  C09J105/04 ,  C09J105/06 ,  C09J189/06 ,  D04H1/4218 ,  D04H1/74 ,  C09J105/12 ,  B32B5/12 ,  B32B5/26 ,  C08L5/12 ,  C03C25/26 ,  B32B19/041 ,  B32B15/14 ,  C09J105/00 ,  B32B37/1207 ,  B32B37/146 ,  D04H1/413 ,  D04H1/64 ,  D04H3/002 ,  E04B1/94 ,  C03C13/06 ,  C08L1/286 ,  C08L3/02 ,  D04H3/004 ,  E04B1/88 ,  C09H11/00 ,  C08J5/043 ,  C03C25/32 ,  C09J11/06 ,  D04H1/587 ,  E04B1/74 ,  C08L89/06 ,  C09J189/005 ,  D04H1/4266 ,  D04H1/724 ,  B32B7/12 ,  B32B19/04 ,  B32B37/18 ,  B32B38/0004 ,  C03C25/321 ,  C03C25/328 ,  C09J5/00 ,  C09J101/28 ,  D04H1/4209 ,  D04H1/593 ,  E04B1/80 ,  E04C2/284 ,  E04D3/352 ,  E04F13/0866 ,  E04B2001/7683

Abstract: An aqueous binder composition for mineral fibers which comprises at least one polyelectrolytic hydrocolloid.

公开(公告)号：US11806445B2

公开(公告)日：2023-11-07

申请号：US16947053

申请日：2020-07-16

Applicant: Wake Forest University Health Sciences

Inventor： Anthony Atala ,  Gayoung Jeong ,  James J. Yoo ,  Sang Jin Lee ,  Young-Joon Seol

IPC: A61F2/10 ,  A61L27/60 ,  B33Y80/00 ,  B33Y70/00 ,  C08L5/08 ,  A61L27/20 ,  C08L89/06 ,  C12N5/071 ,  B29C64/106 ,  B33Y10/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  G01N33/50 ,  B29K75/00 ,  B29K105/00

CPC classification number: A61L27/60 ,  A61F2/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/52 ,  B29C64/106 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08L5/08 ,  C08L89/06 ,  C12N5/0698 ,  G01N33/502 ,  G01N33/5044 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L2300/64 ,  A61L2430/34 ,  B29K2075/00 ,  B29K2105/0061 ,  C12N2502/091 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1305 ,  C12N2502/1323 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2533/80

Abstract: Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics.