公开(公告)号：US12030925B2

公开(公告)日：2024-07-09

申请号：US16415893

申请日：2019-05-17

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Ekta Seth Chhabra ,  Alison Innes ,  Dan Rudin ,  Kara Rice ,  Nancy Wong ,  Suresh Katragadda

IPC: A61K38/00 ,  A61P7/04 ,  C07K14/755

CPC classification number: C07K14/755 ,  A61P7/04 ,  A61K38/00 ,  C07K2319/30

Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D′ domain of VWF and a D3 domain of VWF at a dosing interval.