中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

7 records (took 0.024 seconds)

    Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
    1.
    发明授权
    Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof 有权

    公开(公告)号：US10138291B2

    公开(公告)日：2018-11-27

    申请号：US14413765

    申请日：2013-07-10

    Applicant: Bioverativ Therapeutics Inc.

    Inventor： Ekta Seth Chhabra ,  Tongyao Liu ,  Pei-yun Chang ,  Robert T. Peters ,  John Kulman

    IPC: C07K14/755 ,  A61K38/37 ,  A61P7/04 ,  A61K38/36 ,  A61K47/48 ,  C07K16/00 ,  C12N15/11

    Abstract: The present invention provides a chimeric protein comprising a VWF protein comprising the D′ domain and D3 domain of VWF, one or more XTEN sequence, and a FVIII protein, wherein the VWF fragment, the XTEN sequence, or the FVIII protein are linked to or associated with each other. The chimeric protein can further comprise one or more Ig constant region or a portion thereof (e.g., an Fc region). A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein linked to an XTEN sequence and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein linked to the XTEN sequence. By preventing or inhibiting binding of endogenous VWF to the FVIII protein, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the chimeric protein comprising a FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.

    Chimeric factor VIII polypeptides and uses thereof
    3.
    发明授权
    Chimeric factor VIII polypeptides and uses thereof 有权

    公开(公告)号：US11370827B2

    公开(公告)日：2022-06-28

    申请号：US14371948

    申请日：2013-01-12

    Applicant: BIOVERATIV THERAPEUTICS INC.

    Inventor： Ekta Seth Chhabra ,  Tongyao Liu ,  Robert T Peters ,  Haiyan Jiang

    IPC: A61K38/37 ,  C07K14/755 ,  A61K47/62 ,  C07K16/00

    Abstract: The present invention provides a VWF fragment comprising the D′ domain and D3 domain of VWF, a chimeric protein comprising the VWF fragment and a heterologous moiety, or a chimeric protein comprising the VWF fragment and a FVIII protein and methods of using the same. A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein. By preventing or inhibiting binding of endogenous VWF to the FVIII, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.

    Factor VIII chimeric proteins and uses thereof
    4.
    发明授权
    Factor VIII chimeric proteins and uses thereof 有权

    公开(公告)号：US11192936B2

    公开(公告)日：2021-12-07

    申请号：US15110673

    申请日：2015-01-09

    Applicant: Bioverativ Therapeutics Inc.

    Inventor： Ekta Seth Chhabra ,  Tongyao Liu ,  Robert T. Peters ,  John Kulman

    IPC: C07K14/755 ,  C07K16/00 ,  A61K38/00

    Abstract: The present invention provides a chimeric protein comprising a first polypeptide which comprises a FVIII protein and a first Ig constant region or a portion thereof and a second polypeptide which comprises a VWF protein comprising the D′ domain and D3 domain of VWF, a XTEN sequence having less than 288 amino acids in length, and a second Ig constant region or a portion thereof, wherein the first polypeptide and the second polypeptide are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.

    Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
    5.
    发明授权
    Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof 有权

    公开(公告)号：US11091534B2

    公开(公告)日：2021-08-17

    申请号：US16154310

    申请日：2018-10-08

    Applicant: Bioverativ Therapeutics Inc.

    Inventor： Ekta Seth Chhabra ,  Tongyao Liu ,  Pei-yun Chang ,  Robert T. Peters ,  John Kulman ,  Haiyan Jiang

    IPC: C07K14/755 ,  A61K47/55 ,  A61K38/36 ,  A61K38/37 ,  C07K16/00 ,  C12N15/11

    Abstract: The present invention provides a chimeric protein comprising a VWF protein comprising the D′ domain and D3 domain of VWF, one or more XTEN sequence, and a FVIII protein, wherein the VWF fragment, the XTEN sequence, or the FVIII protein are linked to or associated with each other. The chimeric protein can further comprise one or more Ig constant region or a portion thereof (e.g., an Fc region). A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein linked to an XTEN sequence and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein linked to the XTEN sequence. By preventing or inhibiting binding of endogenous VWF to the FVIII protein, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the chimeric protein comprising a FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.

Patent Agency Ranking