公开(公告)号：US20210277378A1

公开(公告)日：2021-09-09

申请号：US17152239

申请日：2021-01-19

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Volker SCHELLENBERGER ,  Willem P. STEMMER ,  Nathan C. GEETHING ,  Wayne TO ,  Joshua SILVERMAN ,  Chia-wei WANG ,  Benjamin SPINK

IPC: C12N9/64 ,  C07K14/00

Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

公开(公告)号：US20230019286A1

公开(公告)日：2023-01-19

申请号：US17240351

申请日：2021-04-26

Applicant: Bioverativ Therapeutics Inc.

Inventor： Volker SCHELLENBERGER ,  Pei-Yun CHANG ,  Fatbardha VARFAJ ,  John KULMAN ,  Tongyao LIU ,  Garabet G. TOBY ,  Haiyan JIANG ,  Robert PETERS ,  Deping WANG ,  Baisong MEI ,  Joshua SILVERMAN ,  Chia-Wei WANG ,  Benjamin SPINK ,  Nathan GEETHING

IPC: C07K14/755 ,  C07K14/00

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

公开(公告)号：US20190315835A1

公开(公告)日：2019-10-17

申请号：US16369820

申请日：2019-03-29

Applicant: Bioverativ Therapeutics Inc.

Inventor： Volker SCHELLENBERGER ,  Pei-Yun CHANG ,  Fatbardha VARFAJ ,  John KULMAN ,  Tongyao LIU ,  Garabet G. TOBY ,  Haiyan JIANG ,  Robert PETERS ,  Deping WANG ,  Baisong MEI ,  Joshua SILVERMAN ,  Chia-Wei WANG ,  Benjamin SPINK ,  Nathan GEETHING

IPC: C07K14/755 ,  C07K14/00

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.