公开(公告)号：US12060367B2

公开(公告)日：2024-08-13

申请号：US18314445

申请日：2023-05-09

申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  VANDERBILT UNIVERSITY

发明人： Joachim Broeker ,  Jason Abbott ,  Jianwen Cui ,  Stephen W. Fesik ,  Julian Fuchs ,  Andreas Gollner ,  Lorenz Herdeis ,  Tim Hodges ,  Andrew Little ,  Andreas Mantoulidis ,  Jason Phan ,  Juergen Ramharter ,  Dhruba Sarkar ,  Christian Alan Paul Smethurst ,  Kevin Sokol ,  Heinz Stadtmueller ,  Qi Sun ,  Matthias Treu ,  Alex Waterson ,  Birgit Wilding ,  Tobias Wunberg

IPC分类号： C07D498/10 ,  A61P1/00 ,  A61P1/18 ,  A61P11/00 ,  A61P17/00 ,  A61P35/00 ,  C07D519/00

CPC分类号： C07D498/10 ,  A61P1/00 ,  A61P1/18 ,  A61P11/00 ,  A61P17/00 ,  A61P35/00 ,  C07D519/00

摘要： The present invention encompasses compounds of formula (I)






wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.