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公开(公告)号：US20210149361A1
公开(公告)日：2021-05-20
申请号：US16091095
申请日：2017-04-04
发明人： Alois Jungbauer , Astrid Durauer , Nicole Walch , Dominik Sauer , Theresa Scharl-Hirsch , Michael Melcher , Friedrich Leisch
IPC分类号： G05B19/042 , G05B19/418
摘要： The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.
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公开(公告)号：US20240310805A1
公开(公告)日：2024-09-19
申请号：US18442010
申请日：2024-02-14
发明人： Alois Jungbauer , Astrid Durauer , Nicole Walch , Dominik Sauer , Theresa Scharl-Hirsch , Michael Melcher , Friedrich Leisch
IPC分类号： G05B19/042 , G01N21/64 , G01N30/88 , G05B19/418
CPC分类号： G05B19/0428 , G01N21/6486 , G01N30/88 , G05B19/4183 , G05B19/41885
摘要： The invention relates to a method and device which allows in real-time the determination of concentration, purity and potency of a biological product during purification and/or concentration processes in order to intervene into the process, either for process control or real time release. The properties of the process stream are continuously monitored by at least two online sensors and with the aid of multivariate statistical analysis so that concentration, purity and potency is determined in real time.
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