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8 条记录 (耗时 0.012 秒)

    N-(hydroxy-or methoxy-alkyl)-2-(n'-(hydroxy or methoxy-alkyl)-phenyl-amino)-imidazolines-(2) and salts thereof
    1.
    发明授权
    N-(hydroxy-or methoxy-alkyl)-2-(n'-(hydroxy or methoxy-alkyl)-phenyl-amino)-imidazolines-(2) and salts thereof 失效
    N-（羟基 - 或甲氧基 - 烷基）-2-（N' - （羟基或甲氧基 - 烷基） - 苯基 - 氨基） - 咪唑烷 - （2）及其盐

    公开(公告)号：US3773767A

    公开(公告)日：1973-11-20

    申请号：US3773767D

    申请日：1971-03-29

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： STAEHLE H ,  KUMMER W ,  KOEPPE H ,  SAMTLEBEN H

    IPC分类号： C07D233/04 ,  C07D233/50 ,  C07D49/34

    CPC分类号： C07D233/50

    摘要： COMPOUNDS OF THE FORMULA

    1-R5,2-((R1,R2,R3-PHENYL)-N(-R4)-)-2-IMIDAZOLIDINE
    AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS HYPOTENSIVES.

    R IS HYDROGEN OR METHYL, N IS AN INTEGER FROM 1 TO 6, INCLUSIVE, AND X IS AN INTEGER FROM 1 TO 3, INCLUSIVE,

    WHERE

    -CNH2N+1-X(OR)X

    R1, R2 AND R3, WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN, CHLORINE, FLUORINE, BROMINE, CYANO, TRIFLUOROMETHYL, ALKYL OF 1 TO 3 CARBON ATOMS OR ALKOXY OF 1 TO 3 CARBON ATOMS, AND R4 AND R5, WHICH MUST BE DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN OR

    WHEREIN

    Substituted n aminoalkyl arylamino imidazolines-(2)
    2.
    发明授权
    Substituted n aminoalkyl arylamino imidazolines-(2) 失效
    取代的氨基亚氨基亚氨基咪唑啉酮（2）

    公开(公告)号：US3752810A

    公开(公告)日：1973-08-14

    申请号：US3752810D

    申请日：1970-11-16

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： STAEHLE H ,  KOEPPE H ,  KUMMER W ,  SAMTLEBEN H

    IPC分类号： C07D233/50 ,  C07D295/13 ,  C07D87/38 ,  C07D87/40

    CPC分类号： C07D295/13 ,  C07D233/50

    摘要： NOVEL COMPOUNDS SELECTED FROM THE GROUP CONSISTING OF N-AMINOALKYL-ARYLAMINO-IMIDAZOLINES-(2) OF THE FORMULA

    1-R5,2-((R1,R2,R3-PHENYL)-N(-R4)-)-2-IMIDAZOLINE

    WHEREIN R1, R2 AND R3 MAY BE THE SAME OR DIFFERENT AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, FLUORINE, CHLORINE, BROMINE, TRIFLUOROMETHYL, CYANO AND LOWER ALKYL AND LOWER ALKOXY OF 1 TO 7 CARBON ATOMS AND ONE OF 54 AND R5 BEING HYDROGEN WITH THE OTHER BEING -(CH2)N-A, N IS 2 OR 3 AND A IS SELECTED FROM THE GROUP CONSISTING OF DIALKYLAMINO WITH 1 TO 4 CARBON ATOMS IN EACH ALKYL, MORPHOLINO, PYRROLIDINO AND PIPERIDINO AND THEIR NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS HAVING HYPOTENSIVE ACTIVITY, THEIR PREPARATION AND THEIR USE.

    Bicyclic nitrogenous compounds and salts
    3.
    发明授权
    Bicyclic nitrogenous compounds and salts 失效
    双相氮化合物和盐

    公开(公告)号：US3769288A

    公开(公告)日：1973-10-30

    申请号：US3769288D

    申请日：1972-04-12

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： STAEHLE H ,  KOEPPE H ,  KUMMER W ,  SAMTLEBEN H

    IPC分类号： C07D487/04 ,  C07D51/46

    CPC分类号： C07D487/04 ,  Y02P20/55

    摘要： COMPOUNDS OF THE FORMULA

    (R1,R2-PHENYL)-N
    IMIDAZOL-1,2-YLENE)-)

    AND THEIR NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS ARE USEFUL AS HYPOTENSIVES, ANALGESICS, SEDATIVES AND GASTRIC JUICE SECRETION INHIBITORS.

    R1 AND R2 ARE EACH HYDROGEN, HALOGEN, ALKYL OF 1 TO 3 CARBON ATOMS, ALKOXY OF 1 TO 2 CARBON ATOMS, CYANO OR TRIFLUOROMETHYL, R3 IS HYDROGEN OR HYDROXY, AND N IS 0, 1 OR 2,

    WHEREIN

    2,3-dihydro-oxo-imidazo(1,2-a)pyrimidines and salts thereof
    7.
    发明授权
    2,3-dihydro-oxo-imidazo(1,2-a)pyrimidines and salts thereof 失效
    2,3-二氢氧杂咪唑（1,2-A）吡咯烷酮及其盐

    公开(公告)号：US3816422A

    公开(公告)日：1974-06-11

    申请号：US26821572

    申请日：1972-06-30

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： STAHLE H ,  KOEPPE H ,  KUMMER W ,  HOEFKE W

    IPC分类号： C07D487/04 ,  C07D51/46

    CPC分类号： C07D487/04

    摘要： COMPOUNDS OF THE FORMULA

    6-R3,7-R2,8-R1-2,3,5,8-TETRAHYDROIMIDAZO(1,2-A)PYRIMIDIN-

    5-ONE OR

    5-R2,6-R3,8-R1-2,3,7,8-TETRAHYDROIMIDAZO(1,2-A)PYRIMIDIN-

    7-ONE

    WHEREIN R1 IS

    (R4,R5,R6-PHENYL)-(CH2)N-

    WHERE N IS 0 OR 1, AND R4, R5 AND R6, WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH METHYL, ETHYL, FLUORINE, CHLORINE, HYDROGEN, BROMINE, TRIFLUOROMETHYL, CYANO OR METHOXY ONE OF R2 AND R3 IS

    R7-N(-R8)-(CH2)M-

    WHERE M IS AN INTEGER FROM 0 TO 3, INCLUSIVE, R7 IS HYDROGEN OR LOWER ALKYL, R8 IS LOWER ALKYL, AND R7 AND R8, TOGETHER WITH EACH OTHER AND THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, ARE PIPERIDINO, PIPERAZINO, MORPHOLINO OR PYRROLIDINO, AND THE OTHER OF R2 AND R3 IS METHYL OR ETHYL, AND THEIR NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS REGULATORS OF THE CENTRAL NERVOUS SYSTEM AND ESPECIALLY AS HYPOTENSIVES.

    2-phenylimino-imidazolidines,their 2-aniline-2-imidazoline tautomers and salts thereof
    8.
    发明授权
    2-phenylimino-imidazolidines,their 2-aniline-2-imidazoline tautomers and salts thereof 失效
    2-苯基咪唑并咪唑啉酮，它们的2-苯胺二咪唑啉衍生物及其盐

    公开(公告)号：US3804833A

    公开(公告)日：1974-04-16

    申请号：US28077472

    申请日：1972-08-15

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： KUMMER W ,  HOEFKE W ,  STAEHLE H ,  KOEPPE H

    IPC分类号： C07D233/48 ,  C07D233/50 ,  C07D49/30 ,  C07D49/36

    CPC分类号： C07D233/50 ,  C07D233/48

    摘要： COMPOUNDS OF THE FORMULA

    1-R3,2-((R1,R2-PHENYL)-N=),3-R4-IMIDAZOLIDINE

    WHEREIN R1 AND R2, WHICH MAY BE INDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN, CHLORINE, BROMINE, TRIFLUOROMETHYL, CYANO, METHOXY, METHYL OR ETHYL, AND R3 AND R4, WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN, ALKYL OR 1 TO 3 CARBON ATOMS, CYCLOALKYL OF 5 TO 7 CARBON ATOMS OR ALKENYL OF 3 TO 5 CARBON ATOMS, PROVIDED, HOWEVER, THAT R3 AND R4 ARE OTHER THAN BOTH HYDROGEN AT THE SAME TIME, THEIR TAUTOMERS OF THE FORMULA

    1-R3,2-((R1,R2-PHENYL)-NH-)-2-IMIDAZOLINE

    WHEREIN R1 AND R2 HAVE THE MEANINGS DEFINED ABOVE, AND R3 HAS THE MEANINGS DEFINED ABOVE EXCEPT HYDROGEN, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THIER SALTS ARE USEFUL AS HYPOTENSIVES.