公开(公告)号：US10758489B2

公开(公告)日：2020-09-01

申请号：US16369251

申请日：2019-03-29

申请人： BPSI Holdings LLC

发明人： Raxitkumar Y. Mehta ,  George Reyes ,  Jason Teckoe ,  Daniel To

IPC分类号： A61K9/28 ,  A61K9/20 ,  C08K5/092 ,  C09D101/28 ,  C09D7/63

摘要： The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.

公开(公告)号：US20190314286A1

公开(公告)日：2019-10-17

申请号：US16369251

申请日：2019-03-29

申请人： BPSI Holdings LLC

发明人： Raxitkumar Y. Mehta ,  George Reyes ,  Jason Teckoe ,  Daniel To

IPC分类号： A61K9/28 ,  A61K9/20

摘要： The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.

公开(公告)号：US09233074B2

公开(公告)日：2016-01-12

申请号：US14189508

申请日：2014-02-25

申请人： BPSI Holdings, LLC.

发明人： George Reyes ,  Charles R. Cunningham ,  Thomas P. Farrell ,  Cara Young

IPC分类号： A61K9/28

CPC分类号： A61K9/2813 ,  A61K9/2846 ,  A61K9/2886

摘要： The present invention includes pH dependent, dry film coating compositions containing calcium silicate for use on orally-ingestible substrates such as tablets and the like. The film coating compositions can be applied as an aqueous suspension either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is either an enteric or reverse-enteric polymer. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous suspensions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.

摘要翻译： 本发明包括pH依赖性，含有硅酸钙的干膜包衣组合物，用于口服可摄取的底物如片剂等。 膜涂料组合物可以作为水性悬浮液直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是肠溶或反肠溶性聚合物。 还公开了制备干膜涂层的方法，制备相应的水性悬浮液的方法，将涂层施加到基材和涂布的基材本身上的方法。