公开(公告)号：US20250051292A1

公开(公告)日：2025-02-13

申请号：US18718945

申请日：2022-12-13

Applicant: BRACCO IMAGING S.P.A.

Inventor： Sonia GAZZETTO ,  Valeria BOI ,  Andrea BANIN ,  Andrea BARALE

IPC: C07D257/00 ,  C07F11/00

Abstract: The present invention relates to a process for the manufacturing of a mixture comprising the intermediate 1-[bis[2-hydroxy-3-[4,7,10-tris[2-(1,1-dimethylethoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-glucitol. Such intermediate is useful for the synthesis of the dimeric gadolinium complex [μ-[1-[bis[2-(hydroxy-κO)-3-[4,7,10-tris[(carboxy-κO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-κN1,κN4,κN7,κN10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadolinium complex, which can be employed as a contrast agent in the field of diagnostic imaging, and in particular of Magnetic Resonance Imaging (MRI).

公开(公告)号：US20240425527A1

公开(公告)日：2024-12-26

申请号：US18719054

申请日：2022-12-13

Applicant: BRACCO IMAGING S.P.A.

Inventor： Sonia GAZZETTO ,  Valeria BOI ,  Andrea BANIN ,  Andrea BARALE

IPC: C07F5/00

Abstract: The invention relates to a process for the preparation of the gadolinium dimeric contrast agent [p-[1-[bis[2-(hydroxy-KO)-3-[4,7,10-tris[(carboxy-KO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-K/V1,K/V4,K/V7,K/V10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex. Such process includes preparation steps carried out one-pot and without isolation of the obtained intermediates. The gadolinium dimeric contrast agent can be for use in diagnostic imaging, in particular in Magnetic resonance Imaging (MRI).

公开(公告)号：US20230303592A1

公开(公告)日：2023-09-28

申请号：US18017939

申请日：2021-07-26

Applicant: BRACCO IMAGING S.P.A.

Inventor： Andrea BARALE ,  Valeria BOI ,  Aurelia FERRIGATO ,  Sonia GAZZETTO ,  Daniela GIARDINA-PAPA ,  Armando MORTILLARO ,  Laura ORIO ,  Massimo VERANI

IPC: C07F5/00

CPC classification number: C07F5/003

Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [μ-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.