公开(公告)号：US20230303592A1

公开(公告)日：2023-09-28

申请号：US18017939

申请日：2021-07-26

申请人： BRACCO IMAGING S.P.A.

发明人： Andrea BARALE ,  Valeria BOI ,  Aurelia FERRIGATO ,  Sonia GAZZETTO ,  Daniela GIARDINA-PAPA ,  Armando MORTILLARO ,  Laura ORIO ,  Massimo VERANI

IPC分类号： C07F5/00

CPC分类号： C07F5/003

摘要： The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [μ-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.