公开(公告)号：US10010630B2

公开(公告)日：2018-07-03

申请号：US14653793

申请日：2013-12-19

申请人： BRACCO SUISSE S.A.

发明人： Anne Lassus ,  Philippe Bussat ,  Thierry Bettinger

IPC分类号： A61K49/22 ,  A61K9/00 ,  B01J13/02 ,  A61K49/00 ,  A61K9/127

CPC分类号： A61K49/223 ,  A61K9/0019 ,  A61K9/127 ,  A61K49/0002 ,  B01J13/02

摘要： A formulation for preparing gas-filled microvesicles which comprises a phospholipid and a mixture of saturated and unsaturated fatty acids. The gas-filled microvesicles having a stabilizing layer comprising said composition show an increased stability with respect to microvesicles containing only a saturated or an unsaturated fatty acid.

公开(公告)号：US10682429B2

公开(公告)日：2020-06-16

申请号：US15536393

申请日：2015-12-17

申请人： BRACCO SUISSE S.A.

发明人： Philippe Bussat ,  Anne Lassus

IPC分类号： A61K49/22 ,  A61B8/08

摘要： Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.